2. Academic Validation
  3. The role of chemokine receptor 9/chemokine ligand 25 signaling: From immune cells to cancer cells

The role of chemokine receptor 9/chemokine ligand 25 signaling: From immune cells to cancer cells

  • Oncol Lett. 2018 Aug;16(2):2071-2077. doi: 10.3892/ol.2018.8896.
Cong Wang 1,  Zhenghuan Liu 2,  Zhihui Xu 3,  Xian Wu 4,  Dongyang Zhang 4,  Ziqi Zhang 3,  Jianqin Wei 5
Affiliations

Affiliations

  • 1 Department of Hepatopancreatobiliary Surgery, Affiliated Hospital of Qinghai University, Xining, Qinghai 810001, P.R. China.
  • 2 Department of Urology, West China School of Medicine, Sichuan University, Chengdu, Sichuan 610041, P.R. China.
  • 3 State Key Laboratory of Biotherapy and Cancer Center, West China Hospital, Sichuan University and Collaborative Innovation Center, Chengdu, Sichuan 610041, P.R. China.
  • 4 Department of Ultrasound, West China School of Medicine, Sichuan University, Chengdu, Sichuan 610041, P.R. China.
  • 5 The University of Miami Leonard M. Miller School of Medicine, University of Miami, Coral Gables, FL 33136, USA.
PMID: 30008902 DOI: 10.3892/ol.2018.8896
Abstract

Chemokine ligand 25 (CCL25) and Chemokine Receptor 9 (CCR9) are important regulators of migration, proliferation and Apoptosis in leukocytes and Cancer cells. Blocking of the CCR9/CCL25 signal has been demonstrated to be a potential novel Cancer therapy. Research into CCR9 and CCL25 has revealed their associated upstream and downstream signaling pathways; CCR9 is regulated by several immunological factors, including Notch, interleukin 2, interleukin 4 and retinoic acid. Notch in particular, has been revealed to be a crucial upstream regulator of CCR9. Furthermore, proteins including Matrix Metalloproteinases, P-glycoprotein, Ezrin/Radixin/Moesin and Livin are regulated via phosphatidylinositol-3 kinase/protein kinase B, which are in turn stimulated by CCR9/CCL25. This is a review of the current literature on the functions and signaling pathways of CCR9/CCL25.

Keywords

chemokine receptor 9; immune system; tumor suppressor genes.

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