2. Academic Validation
  3. Antibacterial and cytotoxic activities of phenolic constituents from the stem extracts of Spatholobus parviflorus

Antibacterial and cytotoxic activities of phenolic constituents from the stem extracts of Spatholobus parviflorus

  • Nat Prod Res. 2020 May;34(10):1394-1398. doi: 10.1080/14786419.2018.1512990.
Thanika Promchai 1 2,  Pawinee Janhom 1,  Wisanu Maneerat 3,  Roonglawan Rattanajak 4,  Sumalee Kamchonwongpaisan 4,  Stephen G Pyne 5,  Thunwadee Limtharakul 1 6
Affiliations

Affiliations

  • 1 Department of Chemistry and Center of Excellence for Innovation in Chemistry Faculty of Science, Chiang Mai University, Chiang Mai, Thailand.
  • 2 The Graduate School, Chiang Mai University, Chiang Mai, Thailand.
  • 3 School of Science, Mae Fah Luang University, Chiang Rai, Thailand.
  • 4 Medical Molecular Biology Research Unit, National Center for Genetic Engineering and Biotechnology, National Science and Technology Development Agency, Pathumthani, Thailand.
  • 5 School of Chemistry, University of Wollongong, Wollongong, New South Wales, Australia.
  • 6 Research Center on Chemistry for Development of Health Promoting Products from Northern Resources, Chiang Mai University, Chiang Mai, Thailand.
PMID: 30587032 DOI: 10.1080/14786419.2018.1512990
Abstract

A new 2-arylbenzofuran, spathobenzofuran (1), together with ten known compounds including a 2-arylbenzofuran, three pterocarpans and six Isoflavones were isolated from the acetone crude extract of the stems of Spatholobus parviflorus. All compounds were characterised by spectroscopic methods. Compound 4 was active (MIC 8 µg/mL) against Gram-negative Pseudomonas aeruginosa TISTR 781 while compound 2 had modest activity against Gram-positive Staphylococcus aureus TISTR 1466 with a MIC value of 16 µg/mL. All isolated compounds showed no cytotoxicity against Vero and KB cells.

Keywords

Spatholobus parviflorus; antibacterial activity; arylbenzofuran; cytotoxicity.

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