2. Academic Validation
  3. A Brief Review on the Neuroprotective Mechanisms of Vitexin

A Brief Review on the Neuroprotective Mechanisms of Vitexin

  • Biomed Res Int. 2018 Dec 5;2018:4785089. doi: 10.1155/2018/4785089.
Layana Karine F Lima 1,  Suyanne Kássia S Pereira 1,  Ronaldo Dos Santos S Junior 2,  Felipe Pereira da S Santos 2,  Alyandra de Sousa Nascimento 2,  Chistiane Mendes Feitosa 2,  Juliana de Sousa Figuerêdo 2,  Antonio do Nascimento Cavalcante 2,  Edigênia Cavalcante da C Araújo 3,  Mahendra Rai 4
Affiliations

Affiliations

  • 1 Post-Graduate Programs in Pharmaceutical Sciences, Federal University of Piaui, Ininga, 64.049-550, Teresina, Piauí, Brazil.
  • 2 Post-Graduate Programs in Chemistry, Federal University of Piaui, Ininga, 64.049-550, Teresina, Piauí, Brazil.
  • 3 Univasf, Collegiate of Pharmaceutical Sciences, Avenue José de Sá Maniçoba, s/no, Center, CEP 56304-205 Petrolina, PE, Brazil.
  • 4 Department of Biotechnology SGB Amravati University, Amravati PIN-444602, Maharashtra, India.
PMID: 30627560 DOI: 10.1155/2018/4785089
Abstract

The neural dysfunction is triggered by cellular and molecular events that provoke neurotoxicity and neural death. Currently, neurodegenerative diseases are increasingly common, and available treatments are focused on relieving symptoms. Based on the above, in this review we describe the participation of vitexin in the main events involved in the neurotoxicity and cell death process, as well as the use of vitexin as a therapeutic approach to suppress or attenuate neurodegenerative progress. Vitexin contributes to increasing neuroprotective factors and pathways and counteract the targets that induce neurodegeneration, such as redox imbalance, neuroinflammation, abnormal protein aggregation, and reduction of cognitive and/or motor impairment. The results obtained provide substantial evidence to support the scientific exploration of vitexin in these pathologies, since their effects are still little explored for this direction.

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