1. Academic Validation
  2. Entamoeba Histolytica: Updates in Clinical Manifestation, Pathogenesis, and Vaccine Development

Entamoeba Histolytica: Updates in Clinical Manifestation, Pathogenesis, and Vaccine Development

  • Can J Gastroenterol Hepatol. 2018 Dec 2;2018:4601420. doi: 10.1155/2018/4601420.
Micaella Kantor 1 Anarella Abrantes 1 Andrea Estevez 1 Alan Schiller 1 Jose Torrent 1 Jose Gascon 1 Robert Hernandez 1 Christopher Ochner 2
Affiliations

Affiliations

  • 1 Kendall Regional Medical Center, Miami, FL, USA.
  • 2 Hospital Corporation of America, East Florida Division, Fort Lauderdale, FL, USA.
Abstract

Entamoeba histolytica is the responsible Parasite of amoebiasis and remains one of the top three parasitic causes of mortality worldwide. With increased travel and emigration to developed countries, Infection is becoming more common in nonendemic areas. Although the majority of individuals infected with E. histolytica remain asymptomatic, some present with amoebic colitis and disseminated disease. As more is learned about its pathogenesis and the host's immune response, the potential for developing a vaccine holds promise. This narrative review outlines the current knowledge regarding E. histolytica and E. dispar and insight in the development of a vaccine.

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