2. Academic Validation
  3. Isopimarane Diterpenoids from the Rhizomes of Kaempferia marginata and Their Potential Anti-inflammatory Activities

Isopimarane Diterpenoids from the Rhizomes of Kaempferia marginata and Their Potential Anti-inflammatory Activities

  • J Nat Prod. 2020 Jan 24;83(1):14-19. doi: 10.1021/acs.jnatprod.9b00307.
Ratchanaporn Chokchaisiri 1,  Waraluck Chaichompoo 2,  Warangkana Chunglok 3,  Sarot Cheenpracha 1,  Lucksagoon Ganranoo 1,  Nathaporn Phutthawong 1,  Sareeya Bureekaew 4,  Apichart Suksamrarn 2
Affiliations

Affiliations

  • 1 Department of Chemistry, School of Science , University of Phayao , Muang, Phayao 56000 , Thailand.
  • 2 Department of Chemistry and Center of Excellence for Innovation in Chemistry, Faculty of Science , Ramkhamhaeng University , Bangkok 10240 , Thailand.
  • 3 School of Allied Health Sciences and Research Institute for Health Sciences , Walailak University , Nakhon Si Thammarat 80161 , Thailand.
  • 4 Department of Energy Science and Engineering , Vidyasirimedhi Institute of Science and Technology (VISTEC) , Wangchan, Rayong 21210 , Thailand.
PMID: 31873014 DOI: 10.1021/acs.jnatprod.9b00307
Abstract

Six new isopimarane diterpenes, marginaols A-F (1-6), along with eight known compounds (7-14), were isolated from the rhizomes of Kaempferia marginata. The structures and absolute configurations of 1-6 were established on the basis of spectroscopic methods and the experimental and calculated ECD data as well as comparison with the literature values. Most of the isolated compounds were tested for their nitric oxide (NO) inhibitory effects in lipopolysaccharide-activated RAW264.7 cells. Among them, marginaol B (2) was found to reduce NO levels in murine macrophage cells with an IC50 value of 28.1 ± 1.7 μM.

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