2. Academic Validation
  3. Terpenylated coumarins from the root bark of Ailanthus altissima (Mill.) Swingle

Terpenylated coumarins from the root bark of Ailanthus altissima (Mill.) Swingle

  • Phytochemistry. 2020 Jul:175:112361. doi: 10.1016/j.phytochem.2020.112361.
Zhi-Yang Yan 1,  Tian-Ming Lv 1,  Yu-Xi Wang 1,  Shao-Chun Shi 1,  Jing-Jie Chen 1,  Bin-Lin 2,  Qing-Bo Liu 1,  Xiao-Xiao Huang 3,  Shao-Jiang Song 1
Affiliations

Affiliations

  • 1 School of Traditional Chinese Materia Medica, Key Laboratory of Structure-Based Drug Design and Discovery, Ministry of Education, Shenyang Pharmaceutical University, Shenyang, 110016, People's Republic of China.
  • 2 School of Traditional Chinese Materia Medica, Key Laboratory of Structure-Based Drug Design and Discovery, Ministry of Education, Shenyang Pharmaceutical University, Shenyang, 110016, People's Republic of China; School of Pharmaceutical Engineering, Shenyang Pharmaceutical University, Shenyang, 110016, People's Republic of China.
  • 3 School of Traditional Chinese Materia Medica, Key Laboratory of Structure-Based Drug Design and Discovery, Ministry of Education, Shenyang Pharmaceutical University, Shenyang, 110016, People's Republic of China. Electronic address: [email protected].
PMID: 32289598 DOI: 10.1016/j.phytochem.2020.112361
Abstract

Seven undescribed terpenylated Coumarins, named altissimacoumarin I-O, together with seven known compounds, altissimacoumarin C, altissimacoumarin E, altissimacoumarin G, altissimacoumarin H, puberulin, 7-(3-Methyl-2-butenyloxy)-6-methoxycoumarin and artelin were isolated from the root bark of Ailanthus altissima (Mill.) Swingle. Their structures were elucidated by comprehensive spectra data analysis, NMR calculation, DP4+ analysis and ACD/Structure Elucidator software simulation. The absolute configurations of altissimacoumarins K, L, M and N were determined by modified Mosher's method. All isolates were tested for their cytotoxic effect against two hepatoma carcinoma cell lines (HepG2, Hep3B). Altissimacoumarin C exhibited moderate cytotoxic effect against Hep3B cells, with IC50 of 45.21 μM.

Keywords

Ailanthus altissima (Mill.) Swingle; Modified Mosher's method; NMR calculation; Simaroubaceae; Terpenylated coumarins.

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