2. Academic Validation
  3. Resorcylic Acid Lactones from an Ilyonectria sp

Resorcylic Acid Lactones from an Ilyonectria sp

  • J Nat Prod. 2020 May 22;83(5):1505-1514. doi: 10.1021/acs.jnatprod.9b01167.
Jia Zhou 1,  Ying Gao 1,  Jin-Ling Chang 1,  Heng-Yi Yu 2,  Juan Chen 1,  Ming Zhou 1,  Xiang-Gao Meng 3,  Han-Li Ruan 1
Affiliations

Affiliations

  • 1 School of Pharmacy, Tongji Medical College, Huazhong University of Science and Technology, Hubei Key Laboratory of Natural Medicinal Chemistry and Resource Evaluation, Wuhan 430030, People's Republic of China.
  • 2 Department of Pharmacy, Tongji Hospital Affiliated Huazhong University of Science and Technology, Wuhan 430030, People's Republic of China.
  • 3 College of Chemistry, Central China Normal University, Wuhan 430079, People's Republic of China.
PMID: 32323537 DOI: 10.1021/acs.jnatprod.9b01167
Abstract

Twelve new resorcylic acid lactones (RALs) including three new 16-membered RALs (1a, 1b and 2), eight new 14-membered RALs (3-10), and one new 12-membered RAL (11), along with five known 14-membered RALs (12-16), were identified from the fermentation of the soil-derived fungus Ilyonectria sp. sb65. Their structures were established by detailed analyses of 1D and 2D NMR, HRESIMS, and X-ray diffraction crystallography. All new compounds were evaluated for their cytotoxic effects against three human Cancer cell lines, along with their potential as TRAIL sensitizers in TRAIL-resistant A549 human lung adenocarcinoma cells and their in vitro immunosuppressive effects against ConA-induced T-cell and LPS-induced B-cell proliferation.

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