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  3. Dual-Modality Detection of Early-Stage Drug-Induced Acute Kidney Injury by an Activatable Probe

Dual-Modality Detection of Early-Stage Drug-Induced Acute Kidney Injury by an Activatable Probe

  • ACS Sens. 2020 Aug 28;5(8):2457-2466. doi: 10.1021/acssensors.0c00640.
Lingyan Liu 1,  Liping Jiang 2,  Wei Yuan 1,  Zhongkuan Liu 1,  Dongya Liu 1,  Peng Wei 3,  Xinyu Zhang 4,  Tao Yi 1 3
Affiliations

Affiliations

  • 1 Department of Chemistry, Fudan University, 2005 Songhu Road, Shanghai 200438, China.
  • 2 State Key Laboratory of Molecular Engineering of Polymers, Department of Macromolecular Science, Fudan University, 2005 Songhu Road, Shanghai 200438, China.
  • 3 College of Chemistry, Chemical Engineering and Biotechnology, Donghua University, Shanghai 201620, China.
  • 4 School of Public Health, Hongqiao International Institute of Medicine, Shanghai Jiao Tong University School of Medicine, Shanghai 200025, China.
PMID: 32702967 DOI: 10.1021/acssensors.0c00640
Abstract

Early detection of drug-induced acute kidney injury (AKI) is crucial for effective treatment and prevention of further injury. It remains challenging, however, because of the lack of activatable indicators with multimodality imaging capability that could increase the accuracy of diagnosis by mutual verification. Herein, we report an activatable probe, FDOCl-22, that enabled dual-modality detection of the early-stage drug-induced AKI. FDOCl-22 was completely soluble in water and highly sensitive to hypochlorous acid (HOCl). Dramatic increases of both near-infrared (NIR) emission and absorption were observed after reaction with HOCl. A correlation between HOCl concentration and drug-induced AKI was established using FDOCl-22 as a tool. As a consequence, the HOCl-activated probe was able to detect the early-stage drug-induced AKI by dual-modality imaging, irrespective of the drug stimulation time or dosage, by combining NIR fluorescence and photoacoustic imaging.

Keywords

activatable fluorescent probe; biosensor; drug-induced acute kidney injury; dual-modality imaging; early detection.

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