2. Academic Validation
  3. The oncogenic role of protein kinase D3 in cancer

The oncogenic role of protein kinase D3 in cancer

  • J Cancer. 2021 Jan 1;12(3):735-739. doi: 10.7150/jca.50899.
Yan Liu 1 2,  Hang Song 3,  Yehui Zhou 4,  Xinxing Ma 4,  Jing Xu 3,  Zhenghong Yu 5,  Liming Chen 2
Affiliations

Affiliations

  • 1 The Key Laboratory of Bio-Medical Diagnostics, Suzhou Institute of Biomedical Engineering and Technology, Chinese Academy of Sciences, Suzhou 215163, P. R. China.
  • 2 Jiangsu Key Laboratory for Molecular and Medical Biotechnology, Institute of cancer, Department of biochemistry, College of Life Science, Nanjing Normal University, Nanjing 210023, P. R. China.
  • 3 School of Integrated Chinese and Western Medicine, Anhui University of Chinese Medicine, Hefei 230012, P. R.China.
  • 4 The First Affiliated Hospital of Soochow University, Soochow University, Suzhou 215006, P. R. China.
  • 5 Department of Rheumatology and Immunology, Jinling Hospital, Medical School of Nanjing University, Nanjing 210002, P. R.China.
PMID: 33403031 DOI: 10.7150/jca.50899
Abstract

Protein kinase D3 (PRKD3), a serine/threonine kinase, belongs to protein kinase D family, which contains three members: PRKD1, PRKD2, and PRKD3. PRKD3 is activated by many stimuli including phorbol esters, and G-protein-coupled receptor agonists. PRKD3 promotes Cancer cell proliferation, growth, migration, and invasion in various tumor types including colorectal, gastric, hepatic, prostate, and breast Cancer. Accumulating data supports that PRKD3 is a promising therapeutic target for treatment of Cancer. This review discusses the functions and mechanisms of PRKD3 in promoting tumorigenesis and tumor progression of various tumor types as well as the latest developments of small-molecule inhibitors selection for PRKD/PRKD3.

Keywords

Cancer progression; Protein kinase D3.

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