2. Academic Validation
  3. Intelligent hydrogel with both redox and thermo-response based on cellulose nanofiber for controlled drug delivery

Intelligent hydrogel with both redox and thermo-response based on cellulose nanofiber for controlled drug delivery

  • Carbohydr Polym. 2022 Feb 15:278:118943. doi: 10.1016/j.carbpol.2021.118943.
Shiyu Zong 1,  Hankang Wen 1,  Hui Lv 1,  Tong Li 1,  Ruilin Tang 1,  Liujun Liu 1,  Jianxin Jiang 1,  Shengpeng Wang 2,  Jiufang Duan 3
Affiliations

Affiliations

  • 1 MOE Engineering Research Center of Forestry Biomass Materials and Bioenergy, Beijing Forestry University, Beijing 100083, China.
  • 2 Institute of Chinese Medical Sciences, State Key Laboratory of Quality Research in Chinese Medicine, University of Macau, Macao, China.
  • 3 MOE Engineering Research Center of Forestry Biomass Materials and Bioenergy, Beijing Forestry University, Beijing 100083, China. Electronic address: [email protected].
PMID: 34973761 DOI: 10.1016/j.carbpol.2021.118943
Abstract

The purpose of this study is to develop a hydrogel with temperature and redox response to control drug delivery. However, the strength of temperature sensitive N-isopropylacrylamide (NIPAM) hydrogel is weak. Therefore, 2,2,6,6-tetramethylpiperidine-1-oxyl (TEMPO) oxidized cellulose nanofiber (CNF) is introduced to improve this problem. The compressive strength of hydrogels increased by 360% after CNF addition. Meanwhile, N,N'-bis(acryloyl)cystamine (BACy) is introduced into the hydrogels as a cross-linker, imparting redox responsive properties to the hydrogels. Tumor therapeutic drugs are used as model drugs for in vitro release studies. The drug release rate of hydrogel is regulated by temperature and reducing environment. The maximum cumulative release rate of doxorubicin (DOX) is 39.56%, and the Berberine (BBR) is 99.50% after 60 h. The swelling and transparency of hydrogels showed dramatic changes in the range of 30-40 °C. Cytotoxicity experiments demonstrated that the hydrogel had almost no cytotoxicity.

Keywords

Cellulose nanofibers; Drug carrier; Hydrogel; Redox response; Thermo-response.

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