2. Academic Validation
  3. Pharmacological Modulation and (Patho)Physiological Roles of TRPM4 Channel-Part 2: TRPM4 in Health and Disease

Pharmacological Modulation and (Patho)Physiological Roles of TRPM4 Channel-Part 2: TRPM4 in Health and Disease

  • Pharmaceuticals (Basel). 2021 Dec 28;15(1):40. doi: 10.3390/ph15010040.
Csaba Dienes 1 2,  Zsigmond Máté Kovács 1 2,  Tamás Hézső 1 2,  János Almássy 1,  János Magyar 1 3,  Tamás Bányász 1,  Péter P Nánási 1 4,  Balázs Horváth 1 5,  Norbert Szentandrássy 1 6
Affiliations

Affiliations

  • 1 Department of Physiology, Faculty of Medicine, University of Debrecen, 4032 Debrecen, Hungary.
  • 2 Doctoral School of Molecular Medicine, University of Debrecen, 4032 Debrecen, Hungary.
  • 3 Division of Sport Physiology, Department of Physiology, Faculty of Medicine, University of Debrecen, 4032 Debrecen, Hungary.
  • 4 Department of Dental Physiology and Pharmacology, Faculty of Dentistry, University of Debrecen, 4032 Debrecen, Hungary.
  • 5 Faculty of Pharmacy, University of Debrecen, 4032 Debrecen, Hungary.
  • 6 Department of Basic Medical Sciences, Faculty of Dentistry, University of Debrecen, 4032 Debrecen, Hungary.
PMID: 35056097 DOI: 10.3390/ph15010040
Abstract

Transient receptor potential melastatin 4 (TRPM4) is a unique member of the TRPM protein family and, similarly to TRPM5, is CA2+ sensitive and permeable for monovalent but not divalent cations. It is widely expressed in many organs and is involved in several functions; it regulates membrane potential and CA2+ homeostasis in both excitable and non-excitable cells. This part of the review discusses the currently available knowledge about the physiological and pathophysiological roles of TRPM4 in various tissues. These include the physiological functions of TRPM4 in the cells of the Langerhans islets of the pancreas, in various immune functions, in the regulation of vascular tone, in respiratory and Other neuronal activities, in chemosensation, and in renal and cardiac physiology. TRPM4 contributes to pathological conditions such as overactive bladder, endothelial dysfunction, various types of malignant diseases and central nervous system conditions including stroke and injuries as well as in cardiac conditions such as arrhythmias, hypertrophy, and ischemia-reperfusion injuries. TRPM4 claims more and more attention and is likely to be the topic of research in the future.

Keywords

SUR1; TRPM4; cancer; cardiac; central nervous system injury; immune system; neuronal; pancreatic β-cell; urinary bladder; vascular tone.

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