2. Academic Validation
  3. Cytotoxic metabolites from the marine-associated Streptomyces sp. ZZ1944

Cytotoxic metabolites from the marine-associated Streptomyces sp. ZZ1944

  • Phytochemistry. 2022 Sep:201:113292. doi: 10.1016/j.phytochem.2022.113292.
Wenwen Yi 1,  Xiao-Yuan Lian 2,  Zhizhen Zhang 3
Affiliations

Affiliations

  • 1 Ocean College, Zhoushan Campus, Zhejiang University, Zhoushan, 316021, China.
  • 2 College of Pharmaceutical Sciences, Zhejiang University, Hangzhou, 310058, China. Electronic address: [email protected].
  • 3 Ocean College, Zhoushan Campus, Zhejiang University, Zhoushan, 316021, China. Electronic address: [email protected].
PMID: 35780923 DOI: 10.1016/j.phytochem.2022.113292
Abstract

Marine-derived actinomycetes from the genus Streptomycete have a huge potential for the production of metabolites with structural and bioactive uniqueness and diversity. This study described the isolation and structural elucidation of twenty metabolites, including seven previously unreported compounds galbonolide H, galbonolide I, streptophenylpropionic acid A, treptophenylpropyl ester A, streptophenvaleramide A, seco-geldanamycin A and streptorapamycin A, from the marine-associated Streptomycete sp. ZZ1944. Structures of the isolated compounds were elucidated by a combination of extensive NMR spectroscopic analyses, HRESIMS data, optical rotation and ECD calculations. The structure of galbonolide H was also confirmed by a single crystal X-ray diffraction. Both autolytimycin and seco-geldanamycin A showed potent activity against the proliferation of glioma, lung Cancer, colorectal Cancer and breast Cancer cells. Autolytimycin blocked cell cycle of glioma cells and seco-geldanamycin A induced Apoptosis of glioma cells.

Keywords

Cytotoxic activity; Previously undescribed compounds; Streptomyces sp. ZZ1944; Streptomycetaceae; Structure elucidation.

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