2. Academic Validation
  3. The JAK-STAT pathway at 30: Much learned, much more to do

The JAK-STAT pathway at 30: Much learned, much more to do

  • Cell. 2022 Oct 13;185(21):3857-3876. doi: 10.1016/j.cell.2022.09.023.
Rachael L Philips 1,  Yuxin Wang 2,  HyeonJoo Cheon 3,  Yuka Kanno 1,  Massimo Gadina 1,  Vittorio Sartorelli 1,  Curt M Horvath 4,  James E Darnell Jr 5,  George R Stark 2,  John J O'Shea 6
Affiliations

Affiliations

  • 1 Lymphocyte Cell Biology Section, Molecular Immunology and Inflammation Branch, National Institute of Arthritis and Musculoskeletal and Skin Diseases, National Institutes of Health, Bethesda, MD, USA.
  • 2 Department of Cancer Biology, Lerner Research Institute, Cleveland Clinic, Cleveland, OH, USA.
  • 3 Department of Oncology, Wayne State University School of Medicine, Karmanos Cancer Institute, Detroit, MI, USA.
  • 4 Department of Molecular Biosciences, Northwestern University, Evanston, IL, USA.
  • 5 Laboratory of Molecular Cell Biology, The Rockefeller University, New York, NY, USA.
  • 6 Lymphocyte Cell Biology Section, Molecular Immunology and Inflammation Branch, National Institute of Arthritis and Musculoskeletal and Skin Diseases, National Institutes of Health, Bethesda, MD, USA. Electronic address: [email protected].
PMID: 36240739 DOI: 10.1016/j.cell.2022.09.023
Abstract

The discovery of the Janus kinase (JAK)-signal transducer and activator of transcription (STAT) pathway arose from investigations of how cells respond to interferons (IFNs), revealing a paradigm in cell signaling conserved from slime molds to mammals. These discoveries revealed mechanisms underlying rapid gene expression mediated by a wide variety of extracellular polypeptides including cytokines, interleukins, and related factors. This knowledge has provided numerous insights into human disease, from immune deficiencies to Cancer, and was rapidly translated to new drugs for autoimmune, allergic, and infectious diseases, including COVID-19. Despite these advances, major challenges and opportunities remain.

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