2. Academic Validation
  3. Paeonol Ameliorates Ulcerative Colitis in Mice by Modulating the Gut Microbiota and Metabolites

Paeonol Ameliorates Ulcerative Colitis in Mice by Modulating the Gut Microbiota and Metabolites

  • Metabolites. 2022 Oct 8;12(10):956. doi: 10.3390/metabo12100956.
Jiahui Zheng 1 2,  Huan Li 1 2,  Pei Zhang 3,  Shijun Yue 1 4,  Bingtao Zhai 1 2,  Junbo Zou 1 2,  Jiangxue Cheng 1 2,  Chongbo Zhao 1 2,  Dongyan Guo 1 2,  Jing Wang 1 2
Affiliations

Affiliations

  • 1 State Key Laboratory of Research & Development of Characteristic Qin Medicine Resources (Cultivation), Shaanxi University of Chinese Medicine, Xi'an 712046, China.
  • 2 Shaanxi Key Laboratory of Traditional Chinese Medicine Foundation and New Drug Research, Shaanxi University of Chinese Medicine, Xi'an 712046, China.
  • 3 State Key Laboratory of Natural Medicine, China Pharmaceutical University, Nanjing 210009, China.
  • 4 Key Laboratory of Shaanxi Administration of Traditional Chinese Medicine for TCM Compatibility, Shaanxi University of Chinese Medicine, Xi'an 712046, China.
PMID: 36295858 DOI: 10.3390/metabo12100956
Abstract

Ulcerative colitis (UC) is a chronic recurrent inflammatory disease of the gastrointestinal tract. Recent studies demonstrate that the phenolic tannin paeonol (Pae) attenuates UC in mouse models by downregulating inflammatory factors. However, its molecular mechanism for UC treatment has not been explored from the perspective of the gut microbiota and metabolomics. In this study, we investigated the effects of Pae on colonic inflammation, intestinal microbiota and fecal metabolites in 3% dextran sodium sulfate (DSS) induced BALB/c UC mice. Pae significantly improved the clinical index, relieved colonic damage, reduced cytokine levels, and restored the integrity of the intestinal epithelial barrier in UC mice. In addition, Pae increased the abundance of gut microbiota, partially reversed the disturbance of intestinal biota composition, including Lactobacillus and Bacteroides, and regulated metabolite levels, such as bile acid (BA) and short-chain fatty acid (SCFA). In conclusion, our study provides new insight on Pae remission of UC.

Keywords

dextran sodium sulfate; gut microbiota; metabolomics; paeonol; ulcerative colitis.

Figures
Products