2. Academic Validation
  3. The Role of CYP3A in Health and Disease

The Role of CYP3A in Health and Disease

  • Biomedicines. 2022 Oct 24;10(11):2686. doi: 10.3390/biomedicines10112686.
Lyubov S Klyushova 1,  Maria L Perepechaeva 1,  Alevtina Y Grishanova 1
Affiliations

Affiliation

  • 1 Institute of Molecular Biology and Biophysics, Federal Research Center of Fundamental and Translational Medicine, Timakova Str. 2, 630117 Novosibirsk, Russia.
PMID: 36359206 DOI: 10.3390/biomedicines10112686
Abstract

CYP3A is an enzyme subfamily in the Cytochrome P450 (CYP) superfamily and includes isoforms CYP3A4, CYP3A5, CYP3A7, and CYP3A43. CYP3A Enzymes are indiscriminate toward substrates and are unique in that these Enzymes metabolize both endogenous compounds and diverse xenobiotics (including drugs); almost the only common characteristic of these compounds is lipophilicity and a relatively large molecular weight. CYP3A Enzymes are widely expressed in human organs and tissues, and consequences of these enzymes' activities play a major role both in normal regulation of physiological levels of endogenous compounds and in various pathological conditions. This review addresses these aspects of regulation of CYP3A Enzymes under physiological conditions and their involvement in the initiation and progression of diseases.

Keywords

CYP3A; CYP3A endogenous substrates; CYP3A in pathology; CYP3A regulation; drug-metabolizing enzymes.

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