2. Academic Validation
  3. Daphnepedunins A-F, Anti-HIV Macrocyclic Daphnane Orthoester Diterpenoids from Daphne pedunculata

Daphnepedunins A-F, Anti-HIV Macrocyclic Daphnane Orthoester Diterpenoids from Daphne pedunculata

  • J Nat Prod. 2022 Dec 23;85(12):2856-2864. doi: 10.1021/acs.jnatprod.2c00894.
Lingjian Tan 1,  Kouharu Otsuki 1,  Mi Zhang 1,  Takashi Kikuchi 1,  Misaki Okayasu 1,  Isao Azumaya 1,  Di Zhou 2,  Ning Li 2,  Li Huang 3,  Chin-Ho Chen 3,  Wei Li 1
Affiliations

Affiliations

  • 1 Faculty of Pharmaceutical Sciences, Toho University, Miyama 2-2-1, Funabashi, Chiba 274-8510, Japan.
  • 2 School of Traditional Chinese Materia Medica, Shenyang Pharmaceutical University, Shenyang 110016, People's Republic of China.
  • 3 Surgical Science, Department of Surgery, Duke University Medical Center, Durham, North Carolina 27710, United States.
PMID: 36516989 DOI: 10.1021/acs.jnatprod.2c00894
Abstract

From the whole plant of Daphne pedunculata, 12 macrocyclic daphnane Diterpenoids, including six new compounds, daphnepedunins A-F (1-4, 9, and 10), were isolated. Their structures were elucidated by physiochemical and spectroscopic data analysis, the modified Mosher's method, and X-ray crystallography. The isolated compounds were evaluated for anti-HIV activity against HIV-1 Infection in MT4 cells and showed significant anti-HIV activity with IC50 values of 36.3-994 nM. A consideration of the anti-HIV activity of these compounds provided further insight into the structure-activity relationships of macrocyclic daphnane Diterpenoids.

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