2. Academic Validation
  3. Root-shaped antibacterial alginate sponges with enhanced hemostasis and osteogenesis for the prevention of dry socket

Root-shaped antibacterial alginate sponges with enhanced hemostasis and osteogenesis for the prevention of dry socket

  • Carbohydr Polym. 2023 Jan 1:299:120184. doi: 10.1016/j.carbpol.2022.120184.
Danyang Wang 1,  Yinyin Sun 2,  Dongjie Zhang 3,  Xiaowen Kong 4,  Sainan Wang 5,  Jinglin Lu 4,  Fengyuan Liu 4,  Shulai Lu 6,  Hongzhao Qi 7,  Qihui Zhou 8
Affiliations

Affiliations

  • 1 Department of Stomatology, The Affiliated Hospital of Qingdao University, Qingdao University, Qingdao 266003, China; School of Stomatology, Qingdao University, Qingdao 266003, China; Institute for Translational Medicine, The Affiliated Hospital of Qingdao University, Qingdao University, Qingdao 266021, China.
  • 2 Oral Medicine, The People's Hospital of Jimo, Qingdao, Qingdao 266200, China.
  • 3 Department of Gastroenterology, The Affiliated Hospital of Qingdao University, Qingdao 266003, China.
  • 4 School of Stomatology, Qingdao University, Qingdao 266003, China.
  • 5 School of Stomatology, Qingdao University, Qingdao 266003, China; Oral Department of Qingdao Municipal Hospital, Qingdao 266011, China.
  • 6 Oral Department of Qingdao Municipal Hospital, Qingdao 266011, China.
  • 7 Institute for Translational Medicine, The Affiliated Hospital of Qingdao University, Qingdao University, Qingdao 266021, China. Electronic address: [email protected].
  • 8 Department of Stomatology, The Affiliated Hospital of Qingdao University, Qingdao University, Qingdao 266003, China; Institute for Translational Medicine, The Affiliated Hospital of Qingdao University, Qingdao University, Qingdao 266021, China; School of Rehabilitation Sciences and Engineering, University of Health and Rehabilitation Sciences, Qingdao 266071, China. Electronic address: [email protected].
PMID: 36876799 DOI: 10.1016/j.carbpol.2022.120184
Abstract

Tooth extraction commonly causes uncontrolled bleeding, loss of blood clots, and Bacterial infection, leading to the dry socket and bone resorption. Thus, it is highly attractive to design a bio-multifunctional scaffold with outstanding antimicrobial, hemostatic, and osteogenic performances for avoiding dry sockets in clinical applications. Herein, alginate (AG)/quaternized chitosan (Qch)/diatomite (Di) sponges were fabricated via electrostatic interaction, CA2+ cross-linking, as well as lyophilization methods. The composite sponges are facilely made into the shape of the tooth root, which could be well integrated into the alveolar fossa. The Sponge shows a highly interconnected and hierarchical porous structure at the macro/micro/nano levels. The prepared sponges also possess enhanced hemostatic and Antibacterial abilities. Moreover, in vitro cellular assessment indicates that the developed sponges have favorable cytocompatibility and significantly facilitate osteogenesis by upregulating the formation of Alkaline Phosphatase and calcium nodules. The designed bio-multifunctional sponges display great potential for trauma treatment after tooth extraction.

Keywords

Bio-multifunctional sponge; Dry socket; Marine polysaccharide; Osteogenesis; Tooth removal.

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