2. Academic Validation
  3. Photoactivated Hydrogen Sulfide Donor with a Near-Infrared Fluorescence Report System for Accelerated Chronic Wound Healing

Photoactivated Hydrogen Sulfide Donor with a Near-Infrared Fluorescence Report System for Accelerated Chronic Wound Healing

  • Anal Chem. 2023 May 2;95(17):6931-6939. doi: 10.1021/acs.analchem.3c00230.
Fang Yuan 1,  Xiaomeng He 1,  Yurong Lu 2,  Lulu Ning 3,  Xinyue Zhao 1,  Suya Zhang 1,  Feng Guan 2,  Yuan Guo 1,  Jianjian Zhang 1 4
Affiliations

Affiliations

  • 1 Key Laboratory of Synthetic and Natural Functional Molecule Chemistry of Ministry of Education, Key Lab of Modern Separation Science in Shaanxi Province, College of Chemistry and Materials Science, Northwest University, Xi'an, Shaanxi 710127, P. R. China.
  • 2 Shaanxi Provincial Key Laboratory of Biotechnology, Joint International Research Laboratory of Glycobiology and Medicinal Chemistry, College of Life Science, Northwest University, Xi'an, Shaanxi 710127, P. R. China.
  • 3 Shaanxi Provincial Key Laboratory of Papermaking Technology and Specialty Paper Development, College of Bioresources Chemical and Materials Engineering, Shaanxi University of Science & Technology, Xi'an 710021, P. R. China.
  • 4 Qinghai Provincial Key Laboratory of Salt Lake Resources Chemistry, Xining 810008, P. R. China.
PMID: 37074795 DOI: 10.1021/acs.analchem.3c00230
Abstract

Delayed wound healing is one of the major diabetes complications that occur in 25% of diabetic patients. Specific wound management and combination treatment are required to repair the wound, which still remains a challenge with few effective therapies available currently. In this work, a new H2S donor PRO-F, which is characterized by the capability to promote wound healing in diabetes, was designed. PRO-F can be activated by LIGHT without consuming endogenous substances and the accompanying fluorescent signal makes the real-time tracking of released H2S possible. PRO-F is able to deliver H2S in an intracellular environment with moderate release efficiency (50%), which presents cytoprotective effects against excessive Reactive Oxygen Species (ROS) induced damage. Furthermore, the potential of PRO-F to enhance chronic wound healing was validated by employing diabetic models. This work provides new insights into the therapeutic role of H2S donors in complex wound conditions, which should advance the pathophysiological research associated with H2S.

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