2. Academic Validation
  3. Targeting serine-glycine-one-carbon metabolism as a vulnerability in cancers

Targeting serine-glycine-one-carbon metabolism as a vulnerability in cancers

  • Biomark Res. 2023 May 5;11(1):48. doi: 10.1186/s40364-023-00487-4.
Wei Sun # 1 2 3,  Ruochen Liu # 1 2 3 4,  Xinyue Gao 1,  Zini Lin 1,  Hongao Tang 1,  Hongjuan Cui 5 6 7 8,  Erhu Zhao 9 10 11 12
Affiliations

Affiliations

  • 1 State Key Laboratory of Resource Insects, Medical Research Institute, Southwest University, No.2 Tiansheng Road, Beibei District, 400716, Chongqing, China.
  • 2 Chongqing Engineering and Technology Research Center for Silk Biomaterials and Regenerative Medicine, Chongqing, 400716, China.
  • 3 Engineering Research Center for Cancer Biomedical and Translational Medicine, Southwest University, Chongqing, 400715, China.
  • 4 Jinfeng Laboratory, Chongqing, 401329, China.
  • 5 State Key Laboratory of Resource Insects, Medical Research Institute, Southwest University, No.2 Tiansheng Road, Beibei District, 400716, Chongqing, China. [email protected].
  • 6 Chongqing Engineering and Technology Research Center for Silk Biomaterials and Regenerative Medicine, Chongqing, 400716, China. [email protected].
  • 7 Engineering Research Center for Cancer Biomedical and Translational Medicine, Southwest University, Chongqing, 400715, China. [email protected].
  • 8 Jinfeng Laboratory, Chongqing, 401329, China. [email protected].
  • 9 State Key Laboratory of Resource Insects, Medical Research Institute, Southwest University, No.2 Tiansheng Road, Beibei District, 400716, Chongqing, China. [email protected].
  • 10 Chongqing Engineering and Technology Research Center for Silk Biomaterials and Regenerative Medicine, Chongqing, 400716, China. [email protected].
  • 11 Engineering Research Center for Cancer Biomedical and Translational Medicine, Southwest University, Chongqing, 400715, China. [email protected].
  • 12 Jinfeng Laboratory, Chongqing, 401329, China. [email protected].
  • # Contributed equally.
PMID: 37147729 DOI: 10.1186/s40364-023-00487-4
Abstract

The serine-glycine-one-carbon (SGOC) metabolic pathway is critical for DNA methylation, histone methylation, and redox homeostasis, in addition to protein, lipid, and nucleotide biosynthesis. The SGOC pathway is a crucial metabolic network in tumorigenesis, wherein the outputs are required for cell survival and proliferation and are particularly likely to be co-opted by aggressive cancers. SGOC metabolism provides an integration point in cell metabolism and is of crucial clinical significance. The mechanism of how this network is regulated is the key to understanding tumor heterogeneity and overcoming the potential mechanism of tumor recurrence. Herein, we review the role of SGOC metabolism in Cancer by focusing on key Enzymes with tumor-promoting functions and important products with physiological significance in tumorigenesis. In addition, we introduce the ways in which Cancer cells acquire and use one-carbon unit, and discuss the recently clarified role of SGOC metabolic Enzymes in tumorigenesis and development, as well as their relationship with Cancer Immunotherapy and Ferroptosis. The targeting of SGOC metabolism may be a potential therapeutic strategy to improve clinical outcomes in cancers.

Keywords

Ferroptosis; Immunotherapy; Metabolic enzyme inhibitors; Serine-glycine-one-carbon metabolism; Vulnerability.

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