2. Academic Validation
  3. Bioactive mineralized small intestinal submucosa acellular matrix/PMMA bone cement for vertebral bone regeneration

Bioactive mineralized small intestinal submucosa acellular matrix/PMMA bone cement for vertebral bone regeneration

  • Regen Biomater. 2023 May 11:10:rbad040. doi: 10.1093/rb/rbad040.
Xinbao Miao 1,  Shuhui Yang 2,  Jinjin Zhu 3 4,  Zhe Gong 3 4,  Dongze Wu 1,  Juncong Hong 5,  Kaiwen Cai 1,  Jiying Wang 3 4,  Xiangqian Fang 3 4,  Jiye Lu 1,  Guoqiang Jiang 1
Affiliations

Affiliations

  • 1 Department of Spinal Surgery, The First Affiliated Hospital of Ningbo University, Ningbo 315000, Zhejiang, China.
  • 2 School of Materials Science and Engineering, Zhejiang-Mauritius Joint Research Center for Biomaterials and Tissue Engineering, Zhejiang Sci-Tech University, Hangzhou 310018, Zhejiang, China.
  • 3 Department of Orthopedic Surgery, Sir Run Run Shaw Hospital, Zhejiang University School of Medicine, Hangzhou 310016, Zhejiang, China.
  • 4 Key Laboratory of Musculoskeletal System, Degeneration and Regeneration Translational Research of Zhejiang Province, Hangzhou 310016, Zhejiang, China.
  • 5 Department of Anesthesiology, The First People's Hospital of Linping District, Hangzhou 311100, Zhejiang, China.
PMID: 37250976 DOI: 10.1093/rb/rbad040
Abstract

Polymethylmethacrylate (PMMA) bone cement extensively utilized for the treatment of osteoporotic vertebral compression fractures due to its exceptional handleability and mechanical properties. Nevertheless, the clinical application of PMMA bone cement is restricted by its poor bioactivity and excessively high modulus of elasticity. Herein, mineralized small intestinal submucosa (mSIS) was incorporated into PMMA to prepare a partially degradable bone cement (mSIS-PMMA) that provided suitable compressive strength and reduced elastic modulus compared to pure PMMA. The ability of mSIS-PMMA bone cement to promote the attachment, proliferation and osteogenic differentiation of bone marrow mesenchymal stem cells was shown through cellular experiments carried out in vitro, and an animal osteoporosis model validated its potential to improve osseointegration. Considering these benefits, mSIS-PMMA bone cement shows promising potential as an injectable biomaterial for orthopedic procedures that require bone augmentation.

Keywords

PMMA bone cement; mechanical properties; mineralized small intestinal submucosa; osseointegration; osteogenic differentiation.

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