2. Academic Validation
  3. Effective use of a two-dose regimen of dalbavancin to treat prosthetic joint infections and spinal hardware infections

Effective use of a two-dose regimen of dalbavancin to treat prosthetic joint infections and spinal hardware infections

  • Eur J Orthop Surg Traumatol. 2023 Jun 4. doi: 10.1007/s00590-023-03609-8.
James B Doub 1 2,  Talal Alkayali 3,  Anthony Amoroso 3,  Sumon Nandi 4,  Rohit Talwani 3
Affiliations

Affiliations

  • 1 The Doub Laboratory of Translational Bacterial Research, University of Maryland School of Medicine, 725 west Lombard Street, Baltimore, MD, 21201, USA. [email protected].
  • 2 Division of Clinical Care and Research, Institute of Human Virology, University of Maryland School of Medicine, Baltimore, MD, USA. [email protected].
  • 3 Division of Clinical Care and Research, Institute of Human Virology, University of Maryland School of Medicine, Baltimore, MD, USA.
  • 4 Division of Orthopedic Surgery, University of Maryland School of Medicine, Baltimore, MD, USA.
PMID: 37270761 DOI: 10.1007/s00590-023-03609-8
Abstract

Purpose: Dalbavancin is an attractive Antibiotic for the treatment of Gram-positive musculoskeletal infections given its long half-life and prolonged duration in cortical bones. For certain patient populations compliance with Antibiotic regimens can be problematic. Therefore, the purpose of this study was to assess the effectiveness, tolerance, and compliance of treating prosthetic joint and spinal hardware infections with a unique two-dose regimen of dalbavancin.

Methods: Identification of patients that had prosthetic joint infections and spinal hardware infections from January 1, 2017, through December 31, 2021, that had received a two-dose regimen of dalbavancin for these infections was conducted. Patient demographics, Infection recurrence, compliance and adverse drug reactions to the two-dose regimen of dalbavancin were recorded. Furthermore, preserved clinical isolates from these infections were assessed for susceptibility to dalbavancin with microbroth dilutions.

Results: All patients were fully compliant with the two dose dalbavancin regimen and no patient had any adverse reactions to the two-dose dalbavancin regimen. Thirteen of fifteen patients (85.7%) have not had any recurrence of their infections and all preserved clinical isolates showed susceptibility to dalbavancin.

Discussion: The two-dose regimen of dalbavancin is an effective and attractive option in treating prosthetic joint and spinal hardware infections to forgo long term central venous access and ensure compliance. However, the use of rifampin and suppression Antibiotics still needs to be considered when treating these infections. Nonetheless this study supports that a two-dose dalbavancin regimen is a viable alternative in certain clinical settings and consideration for a randomized controlled clinical trial should be entertained to prove its non-inferiority to conventional treatments.

Keywords

Compliance; Dalbavancin; Prosthetic joint infections; Spinal hardware infections.

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