1. Anti-infection
  2. Bacterial
    Antibiotic
  3. Dalbavancin

Dalbavancin (Synonyms: BI 397; MDL 63397)

Cat. No.: HY-17586A
Handling Instructions

Dalbavancin (BI 397) is a semisynthetic lipoglycopeptide antibiotic with potent bactericidal activity against Gram-positive bacteria. Dalbavancin inhibits Staphylococcus aureus and Bacillus anthracis with MIC90s of 0.06 μg/mL and 0.25 μg/mL, respectively.

For research use only. We do not sell to patients.

Dalbavancin Chemical Structure

Dalbavancin Chemical Structure

CAS No. : 171500-79-1

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Description

Dalbavancin (BI 397) is a semisynthetic lipoglycopeptide antibiotic with potent bactericidal activity against Gram-positive bacteria. Dalbavancin inhibits Staphylococcus aureus and Bacillus anthracis with MIC90s of 0.06 μg/mL and 0.25 μg/mL, respectively[1][2].

IC50 & Target

MIC90: 0.06 μg/mL (Staphylococcus aureus) and 0.25 μg/mL (Bacillus anthracis)[1][2]

In Vitro

Dalbavancin is a parenterally administered semisynthetic lipoglycopeptide developed to combat infections caused by resistant gram-positive pathogens. Dalbavancin exhibits potent in vitro bactericidal activity against gram-positive pathogens including S. aureus (MRSA), VISA, and non-VanA strains of VRE. Dalbavancin is developed for the treatment of complicated skin and skin structure infections (cSSSIs), predominantly those caused by MRSA and β-hemolytic streptococci, organisms against which it has shown greater potency than existing glycopeptide therapeutic agents[1][2].

In Vivo

Dalbavancin (15-240 mg/kg; intraperitoneal injection; every 36 h or 72 h; for 14 days; female BALB/c mice) treatment has a survival rate of 80% to 100% of mice with all dose regimens[1].

Animal Model: Female BALB/c mice (6-8 weeks) challenged with Ames strain of B. anthracis[1]
Dosage: 15 mg/kg, 30 mg/kg, 60 mg/kg, 120 mg/kg, 240 mg/kg
Administration: Intraperitoneal injection; every 36 h or 72 h; for 14 days
Result: The efficacy was 80 to 100%, as determined by the rate of survival at 42 days, when treatment was initiated 24 h postchallenge with regimens of 15 to 120 mg/kg every 36 h or 30 to 240 mg/kg every 72 h.
Clinical Trial
Molecular Weight

1816.69

Formula

C₈₈H₁₀₀Cl₂N₁₀O₂₈

CAS No.

171500-79-1

SMILES

O[[email protected]@H]([[email protected]@H](O)[[email protected]@H]1O)[[email protected]](O[[email protected]@H]1CO)OC2=C(C3=CC([[email protected]@](C4=O)([H])NC([[email protected]@](NC([[email protected]](NC([[email protected]@](NC5=O)([H])C6)=O)([H])C(C=C7OC(C=C8[[email protected]]5NC)=C(C=C8)O)=C(C(O)=C7)Cl)=O)([H])C9=CC%10=C(O[[email protected]](O[[email protected]](C(O)=O)[[email protected]@H](O)[[email protected]@H]%11O)[[email protected]@H]%11NC(CCCCCCCCC(C)C)=O)C(OC%12=CC=C6C=C%12)=C9)=O)=CC=C3O)C([[email protected]@](NC([[email protected]](N4)([H])[[email protected]@H](C%13=CC=C(O%10)C(Cl)=C%13)O)=O)([H])C(NCCCN(C)C)=O)=CC(O)=C2

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

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Keywords:

DalbavancinBI 397MDL 63397BI397BI-397MDL63397MDL-63397BacterialAntibioticBacillusanthracissemisyntheticlipoglycopeptideantibioticGram-positiveMRSAcSSSIsInhibitorinhibitorinhibit

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