1. Anti-infection
  2. Bacterial
  3. Dalbavancin hydrochloride

Dalbavancin hydrochloride (Synonyms: MDL-63397 hydrochloride; BI-397 hydrochloride)

Cat. No.: HY-17586 Purity: 99.48%
Handling Instructions

Dalbavancin hydrochloride (MDL-63397 hydrochloride) is a semisynthetic lipoglycopeptide antibiotic with potent bactericidal activity against Gram-positive bacteria. Dalbavancin hydrochloride inhibits Staphylococcus aureus and Bacillus anthracis with MIC90s of 0.06 μg/mL and 0.25 μg/mL, respectively.

For research use only. We do not sell to patients.

Dalbavancin hydrochloride Chemical Structure

Dalbavancin hydrochloride Chemical Structure

CAS No. : 2227366-51-8

Size Price Stock Quantity
10 mM * 1 mL in DMSO USD 422 In-stock
Estimated Time of Arrival: December 31
1 mg USD 60 In-stock
Estimated Time of Arrival: December 31
5 mg USD 180 In-stock
Estimated Time of Arrival: December 31
10 mg USD 288 In-stock
Estimated Time of Arrival: December 31
25 mg USD 528 In-stock
Estimated Time of Arrival: December 31
50 mg USD 720 In-stock
Estimated Time of Arrival: December 31
100 mg USD 1032 In-stock
Estimated Time of Arrival: December 31
200 mg   Get quote  
500 mg   Get quote  

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Based on 2 publication(s) in Google Scholar

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Description

Dalbavancin hydrochloride (MDL-63397 hydrochloride) is a semisynthetic lipoglycopeptide antibiotic with potent bactericidal activity against Gram-positive bacteria. Dalbavancin hydrochloride inhibits Staphylococcus aureus and Bacillus anthracis with MIC90s of 0.06 μg/mL and 0.25 μg/mL, respectively[1][2].

In Vitro

Dalbavancin is a parenterally administered semisynthetic lipoglycopeptide developed to combat infections caused by resistant gram-positive pathogens. Dalbavancin exhibits potent in vitro bactericidal activity against gram-positive pathogens including S. aureus (MRSA), VISA, and non-VanA strains of VRE. Dalbavancin is developed for the treatment of complicated skin and skin structure infections (cSSSIs), predominantly those caused by MRSA and β-hemolytic streptococci, organisms against which it has shown greater potency than existing glycopeptide therapeutic agents[1][2].

In Vivo

Dalbavancin (15-240 mg/kg; intraperitoneal injection; every 36 h or 72 h; for 14 days; female BALB/c mice) treatment has a survival rate of 80% to 100% of mice with all dose regimens[1].

Animal Model: Female BALB/c mice (6-8 weeks) challenged with Ames strain of B. anthracis[1]
Dosage: 15 mg/kg, 30 mg/kg, 60 mg/kg, 120 mg/kg, 240 mg/kg
Administration: Intraperitoneal injection; every 36 h or 72 h; for 14 days
Result: The efficacy was 80 to 100%, as determined by the rate of survival at 42 days, when treatment was initiated 24 h postchallenge with regimens of 15 to 120 mg/kg every 36 h or 30 to 240 mg/kg every 72 h.
Clinical Trial
Molecular Weight

1853.15

Formula

C₈₈H₁₀₁Cl₃N₁₀O₂₈

CAS No.

2227366-51-8

SMILES

O[[email protected]@H]([[email protected]@H](O)[[email protected]@H]1O)[[email protected]](O[[email protected]@H]1CO)OC2=C(C3=CC([[email protected]@](C4=O)([H])NC([[email protected]@](NC([[email protected]](NC([[email protected]@](NC5=O)([H])C6)=O)([H])C(C=C7OC(C=C8[[email protected]]5NC)=C(C=C8)O)=C(C(O)=C7)Cl)=O)([H])C9=CC%10=C(O[[email protected]](O[[email protected]](C(O)=O)[[email protected]@H](O)[[email protected]@H]%11O)[[email protected]@H]%11NC(CCCCCCCCC(C)C)=O)C(OC%12=CC=C6C=C%12)=C9)=O)=CC=C3O)C([[email protected]@](NC([[email protected]](N4)([H])[[email protected]@H](C%13=CC=C(O%10)C(Cl)=C%13)O)=O)([H])C(NCCCN(C)C)=O)=CC(O)=C2.[H]Cl

Shipping

Room temperature in continental US; may vary elsewhere.

Storage
Powder -20°C 3 years
In solvent -80°C 6 months
  -20°C 1 month
Solvent & Solubility
In Vitro: 

H2O : 50 mg/mL (26.98 mM; Need ultrasonic)

DMSO : ≥ 24 mg/mL (12.95 mM)

*"≥" means soluble, but saturation unknown.

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 0.5396 mL 2.6981 mL 5.3962 mL
5 mM 0.1079 mL 0.5396 mL 1.0792 mL
10 mM 0.0540 mL 0.2698 mL 0.5396 mL
*Please refer to the solubility information to select the appropriate solvent.
In Vivo:
  • 1.

    Add each solvent one by one:  10% DMSO    40% PEG300    5% Tween-80    45% saline

    Solubility: ≥ 2.08 mg/mL (1.12 mM); Clear solution

  • 2.

    Add each solvent one by one:  10% DMSO    90% (20% SBE-β-CD in saline)

    Solubility: ≥ 2.08 mg/mL (1.12 mM); Clear solution

  • 3.

    Add each solvent one by one:  10% DMSO    90% corn oil

    Solubility: 2.08 mg/mL (1.12 mM); Clear solution; Need warming

*All of the co-solvents are provided by MCE.
References

Purity: 99.48%

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Keywords:

DalbavancinMDL-63397BI-397MDL63397MDL 63397BI397BI 397BacterialBacillusanthracissemisyntheticlipoglycopeptideantibioticGram-positiveMRSAcSSSIsInhibitorinhibitorinhibit

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Dalbavancin hydrochloride
Cat. No.:
HY-17586
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