2. Academic Validation
  3. Cyclic Peptides from the Opportunistic Pathogen Basidiobolus meristosporus

Cyclic Peptides from the Opportunistic Pathogen Basidiobolus meristosporus

  • J Nat Prod. 2023 Aug 25;86(8):1885-1890. doi: 10.1021/acs.jnatprod.2c01097.
Cheng Zhao 1,  Jiaojiao Qu 1,  Fan Peng 1,  Ruili Lu 1,  Guan-Hu Bao 2,  Bo Huang 1,  Fenglin Hu 1
Affiliations

Affiliations

  • 1 Engineering Research Center of Fungal Biotechnology, Ministry of Education; Research Center on Entomogenous Fungi, Anhui Agricultural University, Hefei, Anhui Province 230036, People's Republic of China.
  • 2 Natural Products Laboratory, State Key Laboratory of Tea Plant Biology and Utilization, Anhui Agricultural University, Hefei, Anhui Province 230036, People's Republic of China.
PMID: 37550948 DOI: 10.1021/acs.jnatprod.2c01097
Abstract

Three new cyclic peptides, meristosporins A, B, and C (1-3), one of which features an unusual amino acid, were isolated from the opportunistic pathogen Basidiobolus meristosporus and identified by 1D, 2D NMR, MS/MS, and Marfey's analysis. The biosynthetic pathway of the hexapeptide meristosporin A (1) was deduced based on nonribosomal peptide synthetase gene clusters analysis. Compounds 1 and 2 showed cytotoxicity to RAW264.7 and 293T cells, respectively. These compounds may be involved in the Fungal injury caused to human cells.

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