2. Academic Validation
  3. Cytotoxic Epipolythiodioxopiperazines from the Deep-Sea-Derived Fungus Exophiala mesophila MCCC 3A00939

Cytotoxic Epipolythiodioxopiperazines from the Deep-Sea-Derived Fungus Exophiala mesophila MCCC 3A00939

  • J Nat Prod. 2023 Oct 27;86(10):2342-2347. doi: 10.1021/acs.jnatprod.3c00534.
Meimei Cheng 1,  Xuli Tang 2,  Zongze Shao 3,  Guoqiang Li 4 5,  Qingqiang Yao 1
Affiliations

Affiliations

  • 1 School of Pharmaceutical Sciences & Institute of Materia Medica, Shandong First Medical University & Shandong Academy of Medical Sciences, National Key Laboratory of Advanced Drug Delivery System, Key Laboratory for Biotechnology Drugs of National Health Commission (Shandong Academy of Medical Sciences), Key Lab for Rare & Uncommon Diseases of Shandong Province, Jinan 250117, Shandong, People's Republic of China.
  • 2 College of Chemistry and Chemical Engineering, Ocean University of China, Qingdao 266100, People's Republic of China.
  • 3 Key Laboratory of Marine Genetic Resources, Third Institute of Oceanography, Ministry of Natural Resources, Xiamen 361005, People's Republic of China.
  • 4 Key Laboratory of Marine Drugs, Chinese Ministry of Education, School of Medicine and Pharmacy, Ocean University of China, Qingdao 266003, People's Republic of China.
  • 5 Laboratory of Marine Drugs and Biological Products, Pilot National Laboratory for Marine Science and Technology, Qingdao 266235, People's Republic of China.
PMID: 37807846 DOI: 10.1021/acs.jnatprod.3c00534
Abstract

Four new aranotin-type epipolythiodioxopiperazines, graphiumins K-N (1-4), along with four known analogues (5-8), were isolated from the deep-sea-derived fungus Exophiala mesophila MCCC 3A00939. Their structures were elucidated by detailed interpretation of NMR and mass spectrometric data. The absolute configuration of the isolates was deduced by a single-crystal X-ray diffraction analysis and the comparisons of experimental electronic circular dichroism (ECD) data with calculated ECD spectra. Graphiumins K (1) and L (2) exhibited cytotoxic activities against the K562, H69AR, and MDA-MB-231 Cancer cells with IC50 values ranging from 2.3 to 5.9 μM.

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