2. Academic Validation
  3. 3D-printed scaffold harboring copper ions combined with near-infrared irradiation for local therapy of cancer

3D-printed scaffold harboring copper ions combined with near-infrared irradiation for local therapy of cancer

  • iScience. 2023 Sep 27;26(10):108076. doi: 10.1016/j.isci.2023.108076.
Hao Wei 1 2,  Dong Chen 3,  Bin Han 3,  Peng Li 3,  Hao Jia 3,  Lizhang Zhu 3,  Hao Yang 1,  Deren Lan 1,  Wei Wei 3,  Haibo Chen 1,  Yongxiang Luo 2,  Yongsheng Zhao 1
Affiliations

Affiliations

  • 1 Department of Nuclear Medicine, Peking University Shenzhen Hospital, Shenzhen 518036, China.
  • 2 Guangdong Key Laboratory for Biomedical Measurements and Ultrasound Imaging, Department of Biomedical Engineering, Shenzhen University Medical School, Shenzhen University, Shenzhen 518055, China.
  • 3 Department of Thyroid and Breast Surgery, Peking University Shenzhen Hospital, Shenzhen 518036, China.
PMID: 37860764 DOI: 10.1016/j.isci.2023.108076
Abstract

Cancer is a major health threat and a leading cause of human death worldwide. Surgical resection is the primary treatment for most cancers; however, some patients develop locoregional recurrence. Here, we developed an in situ Cancer therapeutic system aimed to locally treat Cancer and prevent postoperative recurrence. A functional scaffold, based on alginate/gelatin and crosslinked with copper ions, was fabricated by 3D printing and showed an excellent photothermal effect under near-infrared (NIR) irradiation. The combination of copper ions and NIR effectively killed thyroid Cancer cells and patient-derived organoids, indicating a synergetic and broad-spectrum antitumor effect on thyroid Cancer through the chemo-photothermal therapy. This implantable stent is designed to provide effective treatment in the vicinity of the tumor site and can be degraded without secondary surgery. The copper-loaded hydrogel scaffold may be a potential candidate for local Cancer treatment and pave the way for precise and effective Cancer therapy.

Keywords

Biomaterials; Biomedical Engineering; Cancer; Materials science.

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