2. Academic Validation
  3. Diaporaustalides A-L, Austalide Meroterpenoids from a Plant Endophytic Diaporthe sp

Diaporaustalides A-L, Austalide Meroterpenoids from a Plant Endophytic Diaporthe sp

  • J Nat Prod. 2024 Jan 26;87(1):141-151. doi: 10.1021/acs.jnatprod.3c00986.
Jin-Ling Chang 1,  Jiao Pei 1,  Yin-Hui Zhou 1,  Qian-Xi Ouyang 1,  Chun-Lun Qin 1,  Jia-Yun Hu 1,  Xiang-Gao Meng 2,  Han-Li Ruan 1
Affiliations

Affiliations

  • 1 School of Pharmacy, Tongji Medical College, Huazhong University of Science and Technology, Hubei Key Laboratory of Natural Medicinal Chemistry and Resource Evaluation, Wuhan 430030, People's Republic of China.
  • 2 College of Chemistry, Central China Normal University, Wuhan 430079, People's Republic of China.
PMID: 38128907 DOI: 10.1021/acs.jnatprod.3c00986
Abstract

Twelve new austalide meroterpenoids (1-12) were isolated from the endophytic fungus Diaporthe sp. XC1211. Their structures were elucidated by extensive spectroscopic analysis. The absolute configurations of compounds 1, 3, 4, and 6 were established by single-crystal X-ray diffraction, whereas those for the Others were established by experimental electronic circular dichroism (ECD) data analysis. Compounds 1-12 represent a rare class of austalides with a 24α-CH3. Compounds 2 and 5 demonstrated potent proliferation inhibitory effects against LPS-induced B cells with IC50 values of 6.7 (SI = 3.6) and 3.8 (SI > 13) μM, respectively. Compounds 2 and 5 decreased the secretion of IL-6 in LPS-induced B cells in a dose-dependent manner.

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