2. Academic Validation
  3. Metformin: A promising clinical therapeutical approach for BPH treatment via inhibiting dysregulated steroid hormones-induced prostatic epithelial cells proliferation

Metformin: A promising clinical therapeutical approach for BPH treatment via inhibiting dysregulated steroid hormones-induced prostatic epithelial cells proliferation

  • J Pharm Anal. 2024 Jan;14(1):52-68. doi: 10.1016/j.jpha.2023.08.012.
Tingting Yang 1,  Jiayu Yuan 1,  Yuting Peng 1,  Jiale Pang 1,  Zhen Qiu 1,  Shangxiu Chen 1 2,  Yuhan Huang 1 3,  Zhenzhou Jiang 4,  Yilin Fan 5,  Junjie Liu 6,  Tao Wang 3,  Xueyan Zhou 1,  Sitong Qian 1,  Jinfang Song 1 7,  Yi Xu 2,  Qian Lu 1,  Xiaoxing Yin 1
Affiliations

Affiliations

  • 1 Jiangsu Key Laboratory of New Drug Research and Clinical Pharmacy, Xuzhou Medical University, Xuzhou, Jiangsu, 221004, China.
  • 2 Department of Pharmacy, Affiliated Lianyungang Hospital of Xuzhou Medical University, Lianyungang, Jiangsu, 222061, China.
  • 3 Department of Pharmacy, The Affiliated Hospital of Xuzhou Medical University, Xuzhou, Jiangsu, 221006, China.
  • 4 New Drug Screening Center, Jiangsu Center for Pharmacodynamics Research and Evaluation, China Pharmaceutical University, Nanjing, 210009, China.
  • 5 School of Life Sciences, University of Essex, Essex CO4 3SQ, United Kingdom.
  • 6 Department of Urology, The Affiliated Hospital of Xuzhou Medical University, Xuzhou, Jiangsu, 221006, China.
  • 7 Department of Pharmacy, Affiliated Hospital of Jiangnan University, Wuxi, Jiangsu, 214000, China.
PMID: 38352949 DOI: 10.1016/j.jpha.2023.08.012
Abstract

The occurrence of benign prostate hyperplasia (BPH) was related to disrupted sex steroid Hormones, and metformin (Met) had a clinical response to sex steroid hormone-related gynaecological disease. However, whether Met exerts an antiproliferative effect on BPH via sex steroid Hormones remains unclear. Here, our clinical study showed that along with prostatic epithelial cell (PEC) proliferation, sex steroid Hormones were dysregulated in the serum and prostate of BPH patients. As the major contributor to dysregulated sex steroid Hormones, elevated dihydrotestosterone (DHT) had a significant positive relationship with the clinical characteristics of BPH patients. Activation of adenosine 5'-monophosphate (AMP)-activated protein kinase (AMPK) by Met restored dysregulated sex steroid hormone homeostasis and exerted antiproliferative effects against DHT-induced proliferation by inhibiting the formation of Androgen Receptor (AR)-mediated Yes-associated protein (YAP1)-TEA domain transcription factor (TEAD4) heterodimers. Met's anti-proliferative effects were blocked by AMPK Inhibitor or YAP1 overexpression in DHT-cultured BPH-1 cells. Our findings indicated that Met would be a promising clinical therapeutic approach for BPH by inhibiting dysregulated steroid hormone-induced PEC proliferation.

Keywords

Benign prostatic hyperplasia; DHT; Metformin; Proliferation; Sex steroid hormones homeostasis; YAP1-TEAD4 heterodimer.

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