HBO1, a MYSTerious KAT and its links to cancer

Biochim Biophys Acta Gene Regul Mech. 2024 Sep;1867(3):195045. doi: 10.1016/j.bbagrm.2024.195045.

Akihiko Yokoyama ¹, Hiroyuki Niida ², Tatiana G Kutateladze ³, Jacques Côté ⁴

Affiliations

1 Tsuruoka Metabolomics Laboratory, National Cancer Center, Tsuruoka, Yamagata 997-0052, Japan. Electronic address: [email protected].
2 Department of Molecular Biology, Hamamatsu University School of Medicine, Hamamatsu, Shizuoka 431-3192, Japan.
3 Department of Pharmacology, University of Colorado School of Medicine, Aurora, CO 80045, United States of America. Electronic address: [email protected].
4 St-Patrick Research Group in Basic Oncology, Oncology Division-CHU de Québec-UL Research Center, Laval University Cancer Research Center, Quebec City, QC G1R 3S3, Canada. Electronic address: [email protected].

PMID: 38851533 DOI: 10.1016/j.bbagrm.2024.195045

Abstract

The Histone Acetyltransferase HBO1, also known as KAT7, is a major chromatin modifying enzyme responsible for H3 and H4 acetylation. It is found within two distinct tetrameric complexes, the JADE subunit-containing complex and BRPF subunit-containing complex. The HBO1-JADE complex acetylates lysine 5, 8 and 12 of histone H4, and the HBO1-BRPF complex acetylates lysine 14 of histone H3. HBO1 regulates gene transcription, DNA replication, DNA damage repair, and centromere function. It is involved in diverse signaling pathways and plays crucial roles in development and stem Cell Biology. Recent work has established a strong relationship of HBO1 with the Histone Methyltransferase MLL/KMT2A in acute myeloid leukemia. Here, we discuss functional and pathological links of HBO1 to Cancer, highlighting the underlying mechanisms that may pave the way to the development of novel anti-cancer therapies.

Keywords

Acetylation; Acetyltransferase; Cancer; HBO1; KAT; Transcription.

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