2. Academic Validation
  3. Coaxially fabricated electrospinning near-infrared light-responsive nanofibrous membranes for combating drug-resistant bacteria

Coaxially fabricated electrospinning near-infrared light-responsive nanofibrous membranes for combating drug-resistant bacteria

  • J Hazard Mater. 2025 Jul 15:492:138106. doi: 10.1016/j.jhazmat.2025.138106.
Xiaoyu Jia 1,  Kaiting He 1,  Ling Cai 2,  Yuhui Liu 3,  Henghui Li 1,  Xiaoxiao Dong 4,  Min He 4,  Li Zhang 1,  Guannan Le 5,  Shoulin Wang 6,  Jin Chen 7
Affiliations

Affiliations

  • 1 Center for Global Health, School of Public Health, Nanjing Medical University, Nanjing 211166, China.
  • 2 Center for Global Health, School of Public Health, Nanjing Medical University, Nanjing 211166, China; The Second People's Hospital of Changzhou, the Third Affiliated Hospital of Nanjing Medical University, Changzhou Medical Center, Nanjing Medical University, Changzhou 213003, China.
  • 3 State Key Laboratory of Nuclear Resources and Environment, School of Nuclear Science and Engineering, East China University of Technology, Nanchang 330013, China.
  • 4 Nanjing Medical University Affiliated Nanjing Municipal Center for Disease Control and Prevention, Nanjing 210003, China.
  • 5 Center for Global Health, School of Public Health, Nanjing Medical University, Nanjing 211166, China; School of Chemistry and Chemical Engineering, Southeast University, Nanjing 211189, China.
  • 6 Center for Global Health, School of Public Health, Nanjing Medical University, Nanjing 211166, China. Electronic address: [email protected].
  • 7 Center for Global Health, School of Public Health, Nanjing Medical University, Nanjing 211166, China; School of Chemistry and Chemical Engineering, Southeast University, Nanjing 211189, China; Jiangsu Province Engineering Research Center of Antibody Drug, Key Laboratory of Antibody Technique of National Health Commission, Nanjing Medical University, Nanjing 211166, China. Electronic address: [email protected].
PMID: 40199072 DOI: 10.1016/j.jhazmat.2025.138106
Abstract

Nowadays, the rapid emergence of drug-resistant bacteria has posed a global threat to the public health, leading to increased cost of environmental hygiene and healthcare treatment, which urges the development of safe and efficient Antibacterial strategies. Here, coaxially fabricated electrospun nanofibrous membrane (ENMs) consisted of quercetin (Qu) stabilized selenium nanoparticles (Qu@SeNPs) and electro-synthesized molybdenum disulfide (MoS2) nanosheets were facilely formed as core/shell structure with polyvinyl alcohol (PVA) and α-Lipoic acid (LA) as cross-linker. The obtained ENMs formed by core-shell PVA/MoS2/LA/Qu@SeNPs (PMLQS) showed good air permeability and near-infrared-light photothermal responsiveness to kill bacteria efficiently. Moreover, the obtained ENMs resembling extracellular matrix-like properties showed superior biocompatibility with negligible development toxicity of zebrafish. The Antibacterial experiments indicated that the produced PMLQS fibrous membrane exhibited more pronounced bactericidal activity against Gram-positive (G+) Staphylococcus aureus (S. aureus) and methicillin-resistant S. aureus (MRSA) as compared to that of Gram-negative (G-) Escherichia coli (E. coli). Furthermore, transcriptomic analysis revealed MRSA inactivation by PMLQS ENMs involved disruption of ion transport, antioxidant system, carbohydrate metabolism and energy metabolism. Notably, the MRSA ADI pathway was also blocked supporting the minimized Antibiotic resistance development. Therefore, the constructed near-infrared light-responsive PMLQS nanofibrous membrane held promise in tackling drug-resistant bacteria with enormous environmental and biomedical utilizations.

Keywords

Antibacterial therapy; Coaxial electrospinning nanofibrous membrane; MoS(2) nanosheets; Selenium nanoparticles; Transcriptomic analysis.

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