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  3. A histone deacetylase complex regulates anthocyanin biosynthesis during normal plant growth and development and in response to jasmonate

A histone deacetylase complex regulates anthocyanin biosynthesis during normal plant growth and development and in response to jasmonate

  • Plant Commun. 2025 Nov 4:101587. doi: 10.1016/j.xplc.2025.101587.
Fei Huang 1,  Zhaoxia Zhang 2,  Jiabin Gu 3,  Chao Shen 4,  Dan Wang 3,  Bosi Gao 4,  Yuehui He 5
Affiliations

Affiliations

  • 1 Peking-Tsinghua Center for Life Sciences & State Key Laboratory of Wheat Improvement, School of Advanced Agricultural Sciences, Peking University, Beijing 100871, China; College of Life Sciences and Oceanography, Shenzhen University, Shenzhen 518060, China.
  • 2 Peking-Tsinghua Center for Life Sciences & State Key Laboratory of Wheat Improvement, School of Advanced Agricultural Sciences, Peking University, Beijing 100871, China; Shanghai Center for Plant Stress Biology, CAS Center for Excellence in Molecular Plant Sciences, Chinese Academy of Sciences (CAS), Shanghai 201602, China; University of Chinese Academy of Sciences, Beijing 100049, China.
  • 3 Peking-Tsinghua Center for Life Sciences & State Key Laboratory of Wheat Improvement, School of Advanced Agricultural Sciences, Peking University, Beijing 100871, China.
  • 4 Peking University Institute of Advanced Agricultural Sciences, Shandong Laboratory of Advanced Agricultural Sciences in Weifang, Weifang, Shandong 261325, China.
  • 5 Peking-Tsinghua Center for Life Sciences & State Key Laboratory of Wheat Improvement, School of Advanced Agricultural Sciences, Peking University, Beijing 100871, China; Peking University Institute of Advanced Agricultural Sciences, Shandong Laboratory of Advanced Agricultural Sciences in Weifang, Weifang, Shandong 261325, China. Electronic address: [email protected].
PMID: 41194474 DOI: 10.1016/j.xplc.2025.101587
Abstract

Anthocyanins are plant Pigments that play diverse roles in plant growth, adaptation, and stress tolerance. Anthocyanin biosynthesis is tightly regulated, but the underlying regulatory mechanisms remain unclear. Here, we identify a regulatory module composed of the DNA-binding protein VAL1 (VIVIPAROUS1/ABI3-LIKE 1) and a SIN3 (SWI-INDEPENDENT 3)-like histone deacetylase complex that dynamically regulates anthocyanin biosynthesis in Arabidopsis thaliana. Under normal growth conditions, VAL1 recruits the SNL (SIN3-Like)-HDA19 (HISTONE DEACETYLASE 19) complex (SNL-HDA19c) to the PRODUCTION OF ANTHOCYANIN PIGMENT 1 (PAP1) locus for histone deacetylation. Moreover, the negative regulators of jasmonic acid (JA) signaling, JASMONATE-ZIM DOMAIN (JAZ) proteins, interact with VAL1 and further stabilize the binding of VAL1 and SNL-HDA19c to PAP1 chromatin. These molecular interactions transcriptionally repress PAP1 and inhibit anthocyanin biosynthesis. Upon JA accumulation, JAZs are degraded, resulting in the release of both VAL1 and SNL-HDA19c from the PAP1 chromatin. This release leads to an immediate increase in histone acetylation, promoting transcriptional activation of PAP1 and anthocyanin production. These findings elucidate a regulatory module (VAL1-JAZ-SNL-HDA19c) that represses anthocyanin biosynthesis under normal growth conditions and further reveal how the stress hormone JA rapidly induces anthocyanin production, enabling Plants to adapt to their growth conditions.

Keywords

HDA19; PAP1; SIN3-Like; anthocyanin biosynthesis; histone deacetylase complex; jasmonate.

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