2. Academic Validation
  3. A multifunctional M1-like cell vehicle to intravesically deliver ICG for photodynamic therapy of bladder cancer

A multifunctional M1-like cell vehicle to intravesically deliver ICG for photodynamic therapy of bladder cancer

  • J Control Release. 2026 Jan 10:389:114428. doi: 10.1016/j.jconrel.2025.114428.
Li Sun 1,  Xiaowen Qin 2,  Dingyi Liu 3,  Wenyan Zuo 3,  Heng Wang 3,  Wentao Xu 4,  Bin Zheng 3,  Qi Zhang 3,  Wenbin Xue 3,  Yang Liu 4,  Zhenghong Liu 3,  Yixuan Mou 3,  Yiyang Chen 3,  Chenkai Wang 3,  Xuanyi Zhou 3,  Dahong Zhang 5,  Pu Zhang 6
Affiliations

Affiliations

  • 1 Urology & Nephrology Center, Department of Urology, Zhejiang Provincial People's Hospital (Affiliated People's Hospital), Hangzhou Medical College, Hangzhou 310000, Zhejiang, China; Xingtai Medical Colleage, Xingtai 054000, Hebei, China.
  • 2 Department of Nutrition and Food Hygiene, The National Key Discipline, School of Public Health, Harbin Medical University, Harbin 15008, China.
  • 3 Urology & Nephrology Center, Department of Urology, Zhejiang Provincial People's Hospital (Affiliated People's Hospital), Hangzhou Medical College, Hangzhou 310000, Zhejiang, China.
  • 4 Cancer Center, Department of Interventional Medicine, Zhejiang Provincial People's Hospital (Affiliated People's Hospital), Hangzhou Medical College, Hangzhou 310000, Zhejiang, China.
  • 5 Urology & Nephrology Center, Department of Urology, Zhejiang Provincial People's Hospital (Affiliated People's Hospital), Hangzhou Medical College, Hangzhou 310000, Zhejiang, China. Electronic address: [email protected].
  • 6 Urology & Nephrology Center, Department of Urology, Zhejiang Provincial People's Hospital (Affiliated People's Hospital), Hangzhou Medical College, Hangzhou 310000, Zhejiang, China. Electronic address: [email protected].
PMID: 41265643 DOI: 10.1016/j.jconrel.2025.114428
Abstract

Intravesical drug delivery systems often fail to satisfy the requirement of multifunctionality in one entity, including mucoadhesion, tumor-selective binding and deep tumor-penetration. In this work, we engineered the surface of M1-like macrophages with both tumor-targeted and mucoadhesive ligands (R11) to develop a multifunctional cell vehicle (M1R11) for intravesical delivery of ICG. Remarkably, M1R11 corrected the lysosomal trafficking of ICG, directed it to enter the transcellular pathway and thereby enhance its intra-tumoral penetration. When intravesically applied, the M1R11-delivered ICG displayed much improved photodynamic efficacy, ultimately eradicating orthotopic bladder tumors in most cases and achieving complete pathological response.

Keywords

Bladder Cancer; Direct transfer; Intravesical therapy; Photodynamic therapy; Transcytosis.

Figures
Products