2. Academic Validation
  3. Neuroprotective effect of RMF in a mouse model of sporadic Parkinson's disease

Neuroprotective effect of RMF in a mouse model of sporadic Parkinson's disease

  • Exp Neurol. 2026 Jul:401:115738. doi: 10.1016/j.expneurol.2026.115738.
Umer Anayyat 1,  Xueying Mei 2,  Fen Zhang 3,  Ruiqi Yi 4,  Xiaolu Yang 4,  Zhuohang Yang 3,  Kan Li 2,  Guangsen Zheng 2,  Yunpeng Wei 5,  Xiaomei Wang 6
Affiliations

Affiliations

  • 1 School of Biomedical Engineering Sciences, Shenzhen University, Shenzhen, Guangdong 518061, China; School of Pharmacy, Shenzhen University, Medical School, Shenzhen, Guangdong 518055, China.
  • 2 Hospital of Stomatology, Guanghua School of Stomatology, Sun Yat-sen University, 56 Ling-yuan West Street, Guangzhou 510000, China; Guangdong Provincial Key Laboratory of Stomatology, Sun Yat-sen University, Zhong-Shan Er Road 74, Guangzhou 510080, China.
  • 3 School of Pharmacy, Shenzhen University, Medical School, Shenzhen, Guangdong 518055, China.
  • 4 School of Biomedical Engineering Sciences, Shenzhen University, Shenzhen, Guangdong 518061, China.
  • 5 Faculty of Synthetic Biology, Shenzhen University of Advanced Technology, Shenzhen 518107, China.
  • 6 School of Biomedical Engineering Sciences, Shenzhen University, Shenzhen, Guangdong 518061, China; School of Pharmacy, Shenzhen University, Medical School, Shenzhen, Guangdong 518055, China. Electronic address: [email protected].
PMID: 41862117 DOI: 10.1016/j.expneurol.2026.115738
Abstract

The progressive loss of dopaminergic neurons in the substantia nigra pars compacta (SNpc) due to the aggregation of Lewy bodies is the hallmark of Parkinson's disease (PD). ROS play a key role in the formation of Lewy bodies, thus leading to mitochondrial dysfunction and the Apoptosis of neurons. A rotating magnetic field (RMF) is an emerging noninvasive technique for the prevention of neurodegenerative disorders. To investigate the potential therapeutic effects of RMS in PD, we subjected an experimental mouse model to RMF. CblC mice were injected with 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) (30 mg/kg, i.p., once daily for 5 days), followed by RMF treatment at a frequency and intensity of 4 Hz and 0.4 T, respectively. The daily 2-h RMF treatment was continued for a period of 6 months. We examined the effects of RMF on motor functions, the aggregation of Lewy bodies and the integrity and viability of total and dopaminergic neurons in the SNpc and striatal regions. We further performed transcriptomic analysis of SNpc tissue from PD and SHAM mice. Our results showed that exposure to RMF improved motor functions, enhanced neuronal cell viability and protected neuronal integrity in a PD mouse model. We further showed that RMF diminishes the number of aggregated Lewy bodies in neurons and reduces ROS production. Overall, the results of the transcriptomic analysis revealed that RMF promoted the expression of anti-apoptotic genes rather than proapoptotic genes that are specifically involved in mitochondrial Apoptosis.

Keywords

Neuroinflammation; Rotating magnetic field; Sporadic Parkinson's disease; α-Synuclein aggregates.

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