2. Academic Validation
  3. The metabolism of some food additives related to piperonal in the rabbit

The metabolism of some food additives related to piperonal in the rabbit

  • Xenobiotica. 1980 Apr;10(4):265-70. doi: 10.3109/00498258009033754.
D J Wright,  G M Holder
PMID: 7415207 DOI: 10.3109/00498258009033754
Abstract

1. The metabolism of piperonylidene acetone, and the food additives piperonyl acetone, piperonyl acetate and piperonyl isobutyrate were studied in male rabbits after oral doses of 100 mg/kg. 2. Both piperonylidene acetone and piperonyl acetone were extensively excreted as 4-(3,4-methylenedioxyphenyl)-butan-2-ol to the extent of 71.5% and 81.5% dose respectively in the three-day urine. 3. The esters, piperonyl acetate and piperonyl isobutyrate, were both metabolized to piperonylic acid, to the extent of 70.5% and 11.4% of dose respectively, in the three-day urine.

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