2. Academic Validation
  3. New bioactive taxoids from cell cultures of Taxus baccata

New bioactive taxoids from cell cultures of Taxus baccata

  • J Nat Prod. 1994 Jan;57(1):116-22. doi: 10.1021/np50103a016.
W Ma 1,  G L Park,  G A Gomez,  M H Nieder,  T L Adams,  J S Aynsley,  O P Sahai,  R J Smith,  R W Stahlhut,  P J Hylands
Affiliations

Affiliation

  • 1 PHYTOpharmaceuticals, Inc., San Carlos, California 94070.
PMID: 7908950 DOI: 10.1021/np50103a016
Abstract

Four new taxoids were isolated from cell cultures of Taxus baccata. Their structures were elucidated by spectroscopic analyses. Two were the aglycones corresponding to previously isolated 7-O-xylosides of taxol C [1] and 10-deacetyltaxol C [2]. The third [3] had an N-methylated side-chain, while the fourth, named taxcultine [4], contained an n-propyl group on the side-chain. All four compounds actively promoted tubulin assembly. Taxol C [1] showed potent and selective cytotoxicity in the NCI human cell line screen.

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