2. Academic Validation
  3. Synthesis and antitumor activity of quaternary salts of 2-(2'-oxoalkoxy)-9-hydroxyellipticines

Synthesis and antitumor activity of quaternary salts of 2-(2'-oxoalkoxy)-9-hydroxyellipticines

  • Chem Pharm Bull (Tokyo). 1997 Jan;45(1):134-7. doi: 10.1248/cpb.45.134.
N Harada 1,  T Kawaguchi,  I Inoue,  M Ohashi,  K Oda,  T Hashiyama,  K Tsujihara
Affiliations

Affiliation

  • 1 Lead Optimization Research Laboratory, Tanabe Seiyaku Co., Ltd., Saitama, Japan.
PMID: 9023975 DOI: 10.1248/cpb.45.134
Abstract

Various kinds of water-soluble quaternary salts of 2-(2'-oxoalkoxy)-9-hydroxyellipticines were synthesized in a search for compounds with potent antitumor activity and low toxicity. Some compounds exhibited more potent antitumor activities than elliptinium (1) and SUN 4599 (3). In particular, 2-(3'-methoxy-2'-oxopropanoxy)-9- hydroxy-5,11-dimethyl-6H-pyrido[4,3-b]carbazolium bromide (4d) showed potent antitumor activities against P388 leukemia, colon 26, and Lewis lung carcinoma.

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