2. Academic Validation
  3. Synthesis and 5 alpha-reductase inhibitory activities of benzofuran derivatives with a carbamoyl group

Synthesis and 5 alpha-reductase inhibitory activities of benzofuran derivatives with a carbamoyl group

  • Bioorg Med Chem Lett. 1998 Mar 17;8(6):561-6. doi: 10.1016/s0960-894x(98)00001-8.
K Ishibashi 1,  K Nakajima,  Y Sugioka,  M Sugiyama,  T Hamada,  H Horikoshi,  T Nishi
Affiliations

Affiliation

  • 1 Medicinal Chemistry Research Laboratories, Sankyo Co., Ltd., Tokyo, Japan.
PMID: 9871560 DOI: 10.1016/s0960-894x(98)00001-8
Abstract

A series of 2-phenylbenzofuran derivatives with a diphenylmethylcarbamoyl group at the 5 or 6 position of the benzofuran ring were synthesized and evaluated for rat and human testosterone 5 alpha-reductase inhibitory activities in vitro. They had inhibitory activities against both Enzymes and the 6-carbamoyl derivatives tended to be more potent than the 5-carbamoyl compounds.

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