2. Academic Validation
  3. Development of new chromanol antagonists of leukotriene D4

Development of new chromanol antagonists of leukotriene D4

  • Bioorg Med Chem Lett. 1998 Jul 21;8(14):1791-6. doi: 10.1016/s0960-894x(98)00273-x.
R J Chambers 1,  G W Antognoli,  J B Cheng,  A Marfat,  J S Pillar,  J T Shirley,  J W Watson
Affiliations

Affiliation

  • 1 Central Research Division, Pfizer Inc., Groton, CT 06340, USA.
PMID: 9873435 DOI: 10.1016/s0960-894x(98)00273-x
Abstract

By addressing the issues of potency and metabolism in 3, a new series of LTD4 antagonists represented by (+)-26 was developed which is equipotent to clinical LTD4 antagonists Zafirlukast (1) and Pranlukast (2).

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