2. Academic Validation
  3. A concise synthesis and in vitro cytotoxicity of new labdane diterpenes

A concise synthesis and in vitro cytotoxicity of new labdane diterpenes

  • Bioorg Med Chem Lett. 1998 Dec 1;8(23):3295-8. doi: 10.1016/s0960-894x(98)00603-9.
M Jung 1,  I Ko,  S Lee,  S J Choi,  B H Youn,  S K Kim
Affiliations

Affiliation

  • 1 Department of Chemistry, Yonsei University, Seoul, Korea.
PMID: 9873721 DOI: 10.1016/s0960-894x(98)00603-9
Abstract

A new series of labdane-related diterpenes have been synthesized from (-)-sclareol and assayed in vitro cytotoxicity against mouse and human Cancer cells. A key intermediate, homodrimane and furanolabdane derivatives show good in vitro cytotoxicity comparable to those of mitomycin C and adriamycin.

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