2. Academic Validation
  3. Novel B-ring modified combretastatin analogues: syntheses and antineoplastic activity

Novel B-ring modified combretastatin analogues: syntheses and antineoplastic activity

  • Bioorg Med Chem Lett. 1998 Dec 1;8(23):3371-4. doi: 10.1016/s0960-894x(98)00622-2.
T Hatanaka 1,  K Fujita,  K Ohsumi,  R Nakagawa,  Y Fukuda,  Y Nihei,  Y Suga,  Y Akiyama,  T Tsuji
Affiliations

Affiliation

  • 1 Pharmaceutical Research Laboratories, Ajinomoto Co. Inc., Kawasaki, Japan.
PMID: 9873736 DOI: 10.1016/s0960-894x(98)00622-2
Abstract

A series of B-ring modified combretastatin analogues were synthesized and their inhibitory activity against microtubule assembly, cytotoxic activity against Colon 26 adenocarcinoma Cancer cell line were evaluated. Among these, pyridone derivative (19) showed strong antimitotic activity and cytotoxicity, along with excellent water-solubility.

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