2. PI3K/Akt/mTOR
  3. mTOR
  4. mTORC1-IN-1

mTORC1-IN-1 (T1) is a rapamycin homologue (rapalog) and selective mTORC1 inhibitor. mTORC1-IN-1 regulates cell growth and metabolism and is implicated in a variety of diseases including cancer. mTORC1-IN-1 targets mTORC1 by binding to the FKBP12-FRB complex (docking score = −11.6 kcal/mol).

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mTORC1-IN-1 Chemical Structure

mTORC1-IN-1 Chemical Structure

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mTORC1-IN-1 Related Antibodies

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Description

mTORC1-IN-1 (T1) is a rapamycin homologue (rapalog) and selective mTORC1 inhibitor. mTORC1-IN-1 regulates cell growth and metabolism and is implicated in a variety of diseases including cancer. mTORC1-IN-1 targets mTORC1 by binding to the FKBP12-FRB complex (docking score = −11.6 kcal/mol)[1].

IC50 & Target

mTORC1

 

Molecular Weight

884.15

Formula

C50H77NO12
SMILES

CC([C@@H]1CC[C@@H](C[C@H]([C@H](C2)OC([C@@H]3CCCCN3C(C([C@@]4(O)[C@H](C)CC[C@@H](C[C@H](O)/C=C/C=C/C=C/[C@H](C[C@@H](C)C([C@H](O)[C@@H](/C(C)=C/[C@@H](C)C2=O)O)=O)C)O4)=O)=O)=O)C)CC1)(C)O
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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mTORC1-IN-1 Related Classifications

  • Molarity Calculator

  • Dilution Calculator

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass   Concentration   Volume   Molecular Weight *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

mTORC1-IN-1mTORMammalian target of RapamycinRapamycinInhibitorinhibitorinhibit

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