Poacic acid 

Poacic Acid is a plant-derived stilbenoid with an antifungal activity. Poacic Acid localizes to the yeast cell wall and disrupts the production and assembly of β-1,3-glucan in the fungal cell walls. Poacic Acid exhibits fungicidal activity to Saccharomyces cerevisiae and plasma membrane-compromised Candida albicans mutants^[1].

Poacic Acid (0-512 μg/ml 48h) exhibits significant growth inhibition of Saccharomyces cerevisiae at concentrations at or above 256 μg/mL. Poacic Acid also shows bactericidal effect on Candida albicans mutants with ERG11 and ERG3 gene deletion^[1].
Poacic Acid (1 mM; 1-42 h) increases the production of chitin in the cell wall of Saccharomyces cerevisiae and altered its distribution^[1].
Poacic Acid (512 μg/mL; 36 h) has a reduced inhibitory effect on Saccharomyces cerevisiae in the presence of additional β-glucan or chitin or metal ions^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

342.34

C₁₉H₁₈O₆

160097-32-5

COC1=CC(/C=C/C(O)=O)=CC(/C=C/C2=CC(OC)=C(C=C2)O)=C1O

Room temperature in continental US; may vary elsewhere.

Please store the product under the recommended conditions in the Certificate of Analysis.

• [1]. Yona A, et al. Poacic Acid, a Plant-Derived Stilbenoid, Augments Cell Wall Chitin Production, but Its Antifungal Activity Is Hindered by This Polysaccharide and by Fungal Essential Metals. Biochemistry. 2024 Apr 16;63(8):1051-1065.  [Content Brief]