Integrin alpha 2B beta 3
Integrin alpha 2B beta 3 is the platelet-restricted heterodimer of CD41 and CD61, classically known as glycoprotein IIb/IIIa and the therapeutic target of abciximab. Structurally it combines an alpha-IIb chain cleaved into disulfide-linked heavy and light subunits with the beta-3 chain shared with alpha V beta 3. The receptor exists in equilibrium between bent and extended conformations; activation depends on inside-out signals delivered by talin-1 and kindlin-3 downstream of platelet agonists. Only the high-affinity state binds fibrinogen and von Willebrand factor to mediate aggregation. Mutations in either subunit cause Glanzmann thrombasthenia, and receptor occupancy and function are monitored during antiplatelet therapy.
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Integrin alpha 2B beta 3 Recombinant Proteins (3)
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Recombinant Protein Expression Service
- Codon Optimization
- Gene Synthesis
- Construction of Expression Vector
- Strain Screening
- Protein Expression
- Purification & QC
- Protein Delivery
- Formula: Human
- Molecular Weight: Sf9 insect cells
The EpCAM/TROP1 protein serves as an important homogeneous interacting molecule that promotes direct contact between intestinal epithelial cells (IEC) and intraepithelial lymphocytes (IEL) in the mucosal epithelium. This feature helps establish an immune barrier against mucosal infections. EpCAM/TROP1 Protein, Human (His-SUMO) is the recombinant human-derived EpCAM/TROP1 protein, expressed by E. coli , with N-6*His, N-SUMO labeled tag.
