B7-H4 Protein, Human (HEK293, His-Avi)

B7-H4 protein acts as a negative regulator, inhibiting T-cell-mediated immune responses, including activation, proliferation, cytokine production, and cytotoxicity. When expressed on tumor macrophages, it collaborates with regulatory T-cells to suppress tumor-associated antigen-specific T-cell immunity. B7-H4's involvement extends to promoting epithelial cell transformation, showcasing its multifaceted role in modulating immune responses and processes linked to tumor development. B7-H4 Protein, Human (HEK293, His-Avi) is the recombinant human-derived B7-H4 protein, expressed by HEK293, with C-His, C-Avi labeled tag. The total length of B7-H4 Protein, Human (HEK293, His-Avi) is 230 a.a., with molecular weight of 52-68 kDa.

B7-H4 protein functions as a negative regulator of the T-cell-mediated immune response, exerting inhibitory effects on T-cell activation, proliferation, cytokine production, and the development of cytotoxicity. Particularly significant when expressed on the cell surface of tumor macrophages, B7-H4, in collaboration with regulatory T-cells (Treg), plays a crucial role in suppressing tumor-associated antigen-specific T-cell immunity. Additionally, B7-H4 is implicated in the promotion of epithelial cell transformation, indicating its multifaceted involvement in modulating immune responses and cellular processes associated with tumor development.

Human

HEK293

C-His;C-Avi

Q7Z7D3 (F29-A258)

79679  [NCBI]

52-68 kDa

Greater than 95% as determined by Tris-Bis PAGE.

<1 EU/μg, determined by LAL method.