VTCN1 - V-set domain containing T cell activation inhibitor 1 Gene

Also Known as B7X; B7H4; B7S1; B7-H4; B7h.5; VCTN1; PRO1291

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 79679

About VTCN1

Cytogenetic location: 1p13.1-p12 Genomic coordinates (GRCh38): 1:117,143,587-117,210,927 (from NCBI)

This gene has 6 transcripts (splice variants), 182 orthologues and 15 paralogues. Biased expression in kidney (RPKM 5.0), pancreas (RPKM 2.8) and 9 other tissues.

Summary

This gene encodes a protein belonging to the B7 costimulatory protein family. Proteins in this family are present on the surface of antigen-presenting cells and interact with ligand bound to receptors on the surface of T cells. Studies have shown that high levels of the encoded protein has been correlated with tumor progression. A pseudogene of this gene is located on chromosome 20. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Dec 2011]

VTCN1 Products (3)

mRNA Protein Name
NM_001253849.2 NP_001240778.1 V-set domain-containing T-cell activation inhibitor 1 isoform 2
NM_001253850.2 NP_001240779.1 V-set domain-containing T-cell activation inhibitor 1 isoform 3
NM_024626.4 NP_078902.2 V-set domain-containing T-cell activation inhibitor 1 isoform 1 precursor

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables protein binding IPI
IPI: Inferred from physical interaction
28514442 GOA
Biological Process GO Annotation Evidence References Source
involved in negative regulation of T cell activation IMP
IMP: Inferred from mutant phenotype
16606666 GOA
involved in negative regulation of T cell proliferation IMP
IMP: Inferred from mutant phenotype
16606666 GOA
involved in negative regulation of apoptotic process IMP
IMP: Inferred from mutant phenotype
15878339 GOA
Cellular Component GO Annotation Evidence References Source
located in external side of plasma membrane IDA
IDA: Inferred from direct assay
16606666 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

VTCN1 Protein Structure

V-set

V-set: Immunoglobulin V-set domain (46 - 138)

Ig_3

Ig_3: Immunoglobulin domain (164 - 229)

  • 0
  • 100
  • 200
  • 282 a.a.
Protein Preferred Names Protein Names

V-set domain-containing T-cell activation inhibitor 1

  • B7 family member, H4

VTCN1 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Intra
VTCN1 Q7Z7D3 NCALD Homo sapiens P61601
Anti Tag CoIP
33961781
Intra
VTCN1 Q7Z7D3 NCALD Homo sapiens P61601
Anti Tag CoIP
28514442
Cross: Cross-species interaction Intra: Intraspecies interaction

Recombinant VTCN1 Proteins

Cat. No. Product Name Accession Purity
HY-P7640 B7-H4 Protein, Human (HEK293, Fc) Q7Z7D3-1 (F29-A258) ≥ 95%, as determined by reducing SDS-PAGE.
HY-P72341 B7-H4 Protein, Human (Biotinylated, HEK293, Fc-Avi) Q7Z7D3-1 (F29-A258) ≥ 95%, as determined by reducing SDS-PAGE.
HY-P74395 B7-H4 Protein, Human (HEK293, His) Q7Z7D3-1 (F29-A258) ≥ 95%, as determined by reducing SDS-PAGE.
HY-P77541 B7-H4 Protein, Human (Biotinylated, HEK293, His) Q7Z7D3-1 (F29-A258) ≥ 95%, as determined by reducing SDS-PAGE.
HY-P78073 B7-H4 Protein, Human (Biotinylated, HEK293, His-Avi) Q7Z7D3-1 (F29-A258) ≥ 95%, as determined by Bis-Tris PAGE.

VTCN1 Antibodies

Cat. No. Product Name Application Reactivity
HY-P81427 B7H4 Antibody (YA1172) IHC-P Human
HY-P81427A B7H4 Antibody (YA1172)(PBS only) IHC-P Human

Related Diseases

Diseases Alias
Ovarian Cancer

  • Ovarian Carcinoma

  • Ovarian Neoplasm

  • Malignant Tumour Of Ovary

  • Cancer Of The Ovary

  • Epithelial Ovarian Cancer

  • Neoplasm Of Ovary

  • Ovarian Neoplasms

  • Ovarian Cancers

  • Malignant Neoplasm Of Ovary

  • Primary Malignant Neoplasm Of Ovary

  • Ovarian Cancer, Somatic

  • Malignant Ovarian Tumor

  • Ovary Neoplasm

  • Primary Ovarian Cancer

  • Tumor Of The Ovary

  • Malignant Neoplasm Of The Ovary

  • Malignant Tumor Of The Ovary

  • Ovarian Malignant Tumor

  • OC

  • Ovarian Carcinomas

  • Cancer, Ovarian

  • Cancer Of Ovary

  • Ovary Cancer

  • Ca Ovary
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Clinical Phase
  • Pre-clinical Phase

Clinical Phase

Inhibitory Antibodies (3)
Cat. No. Product Name Effect
Purity Phase
HY-P990059 Puxitatug 99.00% Phase 3
HY-P990953 Zubotamig Inhibitor 96.46% Phase 2
HY-P990996 Felmetatug 99.00% Phase 1

Pre-clinical Phase

Bioactive Molecules (3)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS15721 VTCN1 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS17471 Vtcn1 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS23929 Vtcn1 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown
Inhibitory Antibodies (2)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-P991703 Mocertatug Inhibitor 98% Unkown
HY-P990918 Emiltatug 99% Unkown

Orthologs Information

Species Symbol Source ID
Bos taurus VTCN1 VGNC VGNC:36848
Macaca mulatta VTCN1 VGNC VGNC:79749
Mus musculus VTCN1 MGD MGI:3039619
Rattus norvegicus VTCN1 RGD RGD:1311204
Canis familiaris VTCN1 VGNC VGNC:48315
Felis catus VTCN1 VGNC VGNC:66988
Others VTCN1 NCBI