Mocertatug
Based on 1 Customer Validation
Mocertatug (GSK5733584 antibody) is a humanized IgG1κ antibody targeting B7-H4/VTCN1. Mocertatug can be used to construct ADCs, such as Mocertatug Rezetecan (HY-185280).
For research use only. We do not sell to patients.
- Purity : 98%
- CAS No.: 3042847-92-4
- Molecular Weight:145.246 kDa
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Storage:Shipping with dry ice
Please store the product under the recommended conditions in the Certificate of Analysis.
Biological Activity
Description
Isotype
Human IgG1 kappa
Recommend Isotype Controls
Species Reactivity
Human
IC50 & Target
B7-H4/VTCN1
In Vitro
Mocertatug Rezetecan consists of Mocertatug and the topoisomerase I (TOPO1) inhibitor Rezetecán (HY-147408), and induces cell cycle S-phase arrest, cytotoxicity and bystander killing effect[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
In Vivo
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Gene ID
Accession
Conjugated
Unconjugated
Reconstitution
The product can be reconstituted/diluted with sterile PBS or saline.
Format
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IgG1-kappa
Application
ELISA, FACS, Functional assay
Verified Bioactivity
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Loaded Mocertatug on ProA biosensor, can bind B7-H4 Protein, Human (HEK293, His, HY-P74395) with an affinity constant of 1.401E-07 M as determined in BLI assay. -
Flow cytometric analysis of 1X106 Hela cells labeling B7-H4/VTCN1 with Mocertatug (HY-P991703, red). Cells were stained with the primary antibody at 1/200 dilution for an hour at 4℃. AF488-conjugated Goat Anti-Human IgG H&L (AF488) (HY-P83776) was used as the secondary antibody at 1/1,000 dilution for 30 minutes at 4℃. Human IgG1 kappa (HY-P99001, blue) was used as the isotype control, cells without incubation with primary antibody were used as the unlabeled control (black). -
Immobilized B7-H4 Protein, Human (Biotinylated, HEK293, Fc-Avi, HY-P72341) can bind Mocertatug. The ED50 for this effect is 14.62 ng/mL.
Chemical Information
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CAS No. 3042847-92-4
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Appearance Liquid
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Molecular Weight 145.246 kDa
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Color Colorless to light yellow
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SMILES
N/A
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Synonyms
GSK5733584 antibody; HS-20089 antibody; hu2F7
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Shipping
Shipping with dry ice.
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Formulation
Please refer to the lot-specific COA for specific buffer information.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
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Data Sheet (277 KB)
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SDS (252 KB)
- English - EN (252 KB)
- Français - FR (252 KB)
- Deutsch - DE (252 KB)
- Norwegian - NO (252 KB)
- Español - ES (252 KB)
- Swedish - SV (252 KB)
- Italian - IT (252 KB)
- Korean - KR (252 KB)
- Portuguese - PT (252 KB)
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Inhibitory Antibodies User Guide (603 KB)
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)