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B7H4 Antibody (YA1172)(PBS only)

(Synonyms: B7X; B7H4; B7S1; B7-H4; B7h.5; VCTN1; PRO1291)

B7H4 Antibody (YA1172) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to B7H4.

For research use only. We do not sell to patients.
  • Host:

    Rabbit

  • Isotype:

    IgG

  • Application:

    IHC-P

  • Reactivity :

    Human

  • Formulation:

    Supplied in PBS, pH 7.4.

  • Conjugation:
    Non-conjugated
  • B7H4 Antibody (YA1172)(PBS only) Product Image
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To place orders, for customer services and technical support, please contact: MedChemExpress USA

Tel: 609-228-6898 E-mail: [email protected] [email protected]

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Applications

Application
IHC-P Info
IHC-P: Immunohistochemistry-Paraffin
Dilution Ratio 1:500-1:1000

Product Details

Description

B7H4 Antibody (YA1172) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to B7H4.

  • Host Rabbit
  • Species Reactivity
    Human
  • Observed Molecular Weight
    Observed band size: 60-75 kDa Info
    Note: Due to possible protein modifications or aggregation, the molecular weight should be confirmed by actual measurement, and the predicted value is for reference only.
  • Calculated Molecular Weight Predicted band size: 31 kDa
Immunogen

Recombinant protein of human B7H4

Purification

Affinity Purified

Conjugation

Non-conjugated

Isotype

IgG

Product Properties

  • Appearance

    Solution

  • Formulation

    Supplied in PBS, pH 7.4.

  • Storage & Stability

    Stored at -20°C for 1 year. Avoid repeated freeze / thaw cycles.

  • Shipping

    Shipping with blue ice.

Background

  • Function

    B7-H4 (also known as B7-S1, B7x and VCTN1), a member of the CD28/B7 family, is a transmembrane protein and a T-cell immune co-inhibitory molecule. B7-H4 negatively regulates T cell immune response and promotes immune escape by inhibiting the proliferation

  • Subcellular Localization

    Cell membrane; Single-pass type I membrane protein

  • Expression


    Tissue_specificity:Overexpressed in breast, ovarian, endometrial, renal cell (RCC) and non-small-cell lung cancers (NSCLC) . Expressed on activated T- and B-cells, monocytes and dendritic cells, but not expressed in most normal tissues (at protein level) . Widely expressed, including in kidney, liver, lung, ovary, placenta, spleen and testis

    Induction:Up-regulated by IL6/interleukin-6 and IL10/interleukin-10 and inhibited by CSF2/GM-CSF and IL4/interleukin-4 on antigen-presenting cells (APCs)

  • Isoforms & Post-Translational Modification

    Q7Z7D3 has 4 isomers: Q7Z7D3-1: 30878 Da (predicted); Q7Z7D3-2: 18275 Da (predicted); Q7Z7D3-3: 9875 Da (predicted); Q7Z7D3-4: 20743 Da (predicted).
    N-glycosylated

  • SwissProt ID

    Q7Z7D3

  • Gene ID
    79679 [NCBI]
  • Synonyms

    B7X; B7H4; B7S1; B7-H4; B7h.5; VCTN1; PRO1291

  • Research Field

    Cell Biology

B7H4 Antibody (YA1172)(PBS only) Related Classifications

MOQ
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100 mg

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Measured by its ability to inhibit anti-CD3-induced proliferation of stimulated CTLL-2 mouse cytotoxic T cells. The ED50 this effect is 0.8023 μg/ml, corresponding to a specific activity is 1246.42 units/mg.

Assay Types
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  • B7H4 Antibody (YA1172)(PBS only) Product Image