B7H4 Antibody (YA1172)(PBS only)
(別名: B7X; B7H4; B7S1; B7-H4; B7h.5; VCTN1; PRO1291)B7H4 Antibody (YA1172) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to B7H4.
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Host:
Rabbit
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Isotype:
IgG
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Application:
IHC-P
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Reactivity :
Human
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Formulation:
Supplied in PBS, pH 7.4.
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Conjugation:
Non-conjugated
Applications
| Application |
IHC-P
IHC-P: Immunohistochemistry-Paraffin
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|---|---|
| Dilution Ratio | 1:500-1:1000 |
Product Details
B7H4 Antibody (YA1172) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to B7H4.
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Host Rabbit
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Species ReactivityHuman
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Observed Molecular WeightObserved band size: 60-75 kDa
Note: Due to possible protein modifications or aggregation, the molecular weight should be confirmed by actual measurement, and the predicted value is for reference only.
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Calculated Molecular Weight Predicted band size: 31 kDa
Recombinant protein of human B7H4
Affinity Purified
Non-conjugated
IgG
Product Properties
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Appearance
Liquid
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Formulation
Supplied in PBS, pH 7.4.
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Storage & Stability
Stored at -20°C for 1 year. Avoid repeated freeze / thaw cycles.
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輸送条件
Shipping with blue ice.
Background
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Function
Negatively regulates T-cell-mediated immune response by inhibiting T-cell activation, proliferation, cytokine production and development of cytotoxicity. When expressed on the cell surface of tumor macrophages, plays an important role, together with regulatory T-cells (Treg), in the suppression of tumor-associated antigen-specific T-cell immunity. Involved in promoting epithelial cell transformation
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Subcellular Localization
Cell membrane; Single-pass type I membrane protein
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Expression
Tissue_specificity:Overexpressed in breast, ovarian, endometrial, renal cell (RCC) and non-small-cell lung cancers (NSCLC) . Expressed on activated T- and B-cells, monocytes and dendritic cells, but not expressed in most normal tissues (at protein level) . Widely expressed, including in kidney, liver, lung, ovary, placenta, spleen and testis
Induction:Up-regulated by IL6/interleukin-6 and IL10/interleukin-10 and inhibited by CSF2/GM-CSF and IL4/interleukin-4 on antigen-presenting cells (APCs) -
Isoforms & Post-Translational Modification
Q7Z7D3 has 4 isomers: Q7Z7D3-1: 30878 Da (predicted); Q7Z7D3-2: 18275 Da (predicted); Q7Z7D3-3: 9875 Da (predicted); Q7Z7D3-4: 20743 Da (predicted).
N-glycosylated -
SwissProt ID
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別名
B7X; B7H4; B7S1; B7-H4; B7h.5; VCTN1; PRO1291
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Research Field
Cell Biology
ドキュメント
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