2. Recombinant Proteins
  3. Cytokines and Growth Factors Receptor Proteins
  4. Chemokine & Receptors G-Protein-Coupled Receptors (GPCRs)
  5. CC Chemokine Receptor Chemokine Receptor
  6. CCR8
  7. CCR8 Protein, Mouse (Cell-Free, His)

CCR8 Protein, Mouse (Cell-Free, His)

Cat. No.: HY-P702237
Handling Instructions

The CCR8 protein serves as a receptor for the CCL1/SCY1/TCA-3 chemokine and is critical for mediating cellular responses. Its interaction with CCL1 coordinates key chemotactic signaling that regulates immune cell migration and positioning in the cellular microenvironment. CCR8 Protein, Mouse (Cell-Free, His) is the recombinant mouse-derived CCR8 protein, expressed by E. coli Cell-free , with N-10*His labeled tag. The total length of CCR8 Protein, Mouse (Cell-Free, His) is 353 a.a., with molecular weight of 41.5 kDa.

For research use only. We do not sell to patients.

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Description

The CCR8 protein serves as a receptor for the CCL1/SCY1/TCA-3 chemokine and is critical for mediating cellular responses. Its interaction with CCL1 coordinates key chemotactic signaling that regulates immune cell migration and positioning in the cellular microenvironment. CCR8 Protein, Mouse (Cell-Free, His) is the recombinant mouse-derived CCR8 protein, expressed by E. coli Cell-free , with N-10*His labeled tag. The total length of CCR8 Protein, Mouse (Cell-Free, His) is 353 a.a., with molecular weight of 41.5 kDa.
Background

CCR8 Protein serves as the receptor for the CCL1/SCY1/TCA-3 chemokine, indicating its crucial role in mediating cellular responses to this specific chemokine ligand. The interaction between CCR8 and CCL1 is pivotal in orchestrating chemotactic signaling events that regulate immune cell migration and positioning within the cellular microenvironment. As a receptor for CCL1, CCR8 contributes to the intricate network of chemokine signaling, playing a significant role in immune responses and cellular communication within the immune system.
Species

Mouse
Source

E. coli Cell-free
Tag

N-10*His
Accession

P56484 (M1-L353)
Gene ID

12776
Molecular Construction
N-term
10*His
CCR8 (M1-L353)
Accession # P56484
C-term
Synonyms
C-C chemokine receptor type 8; CD_antigen: CDw198 Cmkbr8; Ter1; C-C CKR-8; CC-CKR-8; CCR-8
AA Sequence

MDYTMEPNVTMTDYYPDFFTAPCDAEFLLRGSMLYLAILYCVLFVLGLLGNSLVILVLVGCKKLRSITDIYLLNLAASDLLFVLSIPFQTHNLLDQWVFGTAMCKVVSGLYYIGFFSSMFFITLMSVDRYLAIVHAVYAIKVRTASVGTALSLTVWLAAVTATIPLMVFYQVASEDGMLQCFQFYEEQSLRWKLFTHFEINALGLLLPFAILLFCYVRILQQLRGCLNHNRTRAIKLVLTVVIVSLLFWVPFNVALFLTSLHDLHILDGCATRQRLALAIHVTEVISFTHCCVNPVIYAFIGEKFKKHLMDVFQKSCSHIFLYLGRQMPVGALERQLSSNQRSSHSSTLDDIL

Molecular Weight

41.5 kDa
Purity

Greater than 90% as determined by reducing SDS-PAGE.
Endotoxin Level

<1 EU/μg, determined by LAL method.
Documentation
Handling Instructions (2659 KB)

CCR8 Protein, Mouse (Cell-Free, His) Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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The reconstitution calculator equation

Volume (to add to vial) = Mass (in vial) ÷ Desired Reconstitution Concentration

Volume (to add to vial) = Mass (in vial) ÷ Desired Reconstitution Concentration
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The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
× = ×
C1   V1   C2   V2

The specific activity calculator equation

Specific Activity (Unit/mg) = 106 ÷ Biological Activity (ED50)

Specific Activity (Unit/mg) = 106 ÷ Biological Activity (ED50)
Unit/mg = 106 ÷ ng/mL

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