ICAM-4 Protein, Human (HEK293, Fc)

Intercellular adhesion molecule 4 isoform 3 is expressed on RBCs, erythroid precursor cells, and on other blood cells including T and B cells. Intercellular adhesion molecule 4 isoform 3 belongs to the immunoglobulin superfamily (IgSF) consisting of five members designated ICAM1 to ICAM5. Intercellular adhesion molecule 4 isoform 3 is part of the Rh macromolecular complex consisting of Rh polypeptides (RhD and RhCE) and the Rh-associated glycoprotein (RhAG). Intercellular adhesion molecule 4 isoform 3 maintains close contact between the RBC surface and vascular endothelium and also plays a role in various normal and pathologic conditions, including erythropoiesis and microvascular occlusions during painful crises of sickle cell disease, respectively. ICAM-4 Protein, Human (HEK293, Fc) is the recombinant human-derived ICAM-4 protein, expressed by HEK293 , with C-hFc labeled tag. The total length of ICAM-4 Protein, Human (HEK293, Fc) is 250 a.a., with molecular weight of ~55 & 33 KDa, respectively.

Intercellular adhesion molecule 4 isoform 3 is expressed on RBCs, erythroid precursor cells, and on other blood cells including T and B cells. Intercellular adhesion molecule 4 isoform 3 belongs to the immunoglobulin superfamily (IgSF) consisting of five members designated ICAM1 to ICAM5. Intercellular adhesion molecule 4 isoform 3 is part of the Rh macromolecular complex consisting of Rh polypeptides (RhD and RhCE) and the Rh-associated glycoprotein (RhAG). Intercellular adhesion molecule 4 isoform 3 maintains close contact between the RBC surface and vascular endothelium and also plays a role in various normal and pathologic conditions, including erythropoiesis and microvascular occlusions during painful crises of sickle cell disease, respectively. Intercellular adhesion molecule 4 isoform 3 encodes the Landsteiner-Wiener (LW) blood group antigen(s) that belongs to the immunoglobulin (Ig) superfamily, and that shares similarity with the intercellular adhesion molecule (ICAM) protein family. Intercellular adhesion molecule 4 isoform 3 contains 2 Ig-like C2-type domains and binds to the leukocyte adhesion LFA-1 protein^[1][2][3].

Human

HEK293

C-hFc

U5U6P8 (A23-G272)

3386  [NCBI]

Approximately 55&33 kDa.

Greater than 85% as determined by reducing SDS-PAGE

<1 EU/μg, determined by LAL method.