ICAM4 - intercellular adhesion molecule 4 (Landsteiner-Wiener blood group) Gene

Homo sapiens

Also known as LW; CD242

Gene ID: 3386 | Gene type: protein coding

About ICAM4

Cytogenetic location: 19p13.2 Genomic coordinates (GRCh38): 19:10,286,955-10,288,520 (from NCBI)

This gene has 3 transcripts (splice variants), 85 orthologues, 4 paralogues and is associated with 1 phenotype. Biased expression in lung (RPKM 3.3), bone marrow (RPKM 3.1) and 13 other tissues.

Summary

This gene encodes the Landsteiner-Wiener (LW) blood group antigen(s) that belongs to the immunoglobulin (Ig) superfamily, and that shares similarity with the intercellular adhesion molecule (ICAM) protein family. This ICAM protein contains 2 Ig-like C2-type domains and binds to the leukocyte adhesion LFA-1 protein. The molecular basis of the LW(A)/LW(B) blood group antigens is a single aa variation at position 100; Gln-100=LW(A) and Arg-100=LW(B). Alternative splicing results in multiple transcript variants encoding distinct isoforms. [provided by RefSeq, Jul 2008]

ICAM4 Products(2)

mRNA	Protein	Name
NM_001039132.3	NP_001034221.1	intercellular adhesion molecule 4 isoform 3 precursor
NM_001544.5	NP_001535.1	intercellular adhesion molecule 4 isoform 1 precursor

ICAM4 Protein Structure

ICAM_N

0
100
200
271 a.a.

Protein Preferred Names

Protein Names

intercellular adhesion molecule 4

CD242 antigen

Recombinant ICAM4 Proteins

Cat. No.	Product Name	Accession	Purity
HY-P76392	ICAM-4 Protein, Human (HEK293, Fc)	U5U6P8 (A23-G272)	≥95%

Related Diseases

Diseases

Alias

Blood Group System, Landsteiner-Wiener

LW	Landsteiner-Wiener Blood Group System

Anemia, Congenital Dyserythropoietic, Type Iv

CDAN4	Congenital Dyserythropoietic Anemia Type Iv
Congenital Dyserythropoietic Anemia Type 4	Cda Iv
Cda Due To Klf1 Mutation	Cda Type 4
Cda Type Iv	Congenital Dyserythropoietic Anemia Due To Klf1 Mutation
Cda, Type Iv	Dyserythropoietic Anemia, Congenital, Type Iv
Congenital Dyserythropoietic Anaemia Due To Klf1 Mutation	Congenital Dyserythropoietic Anaemia Type 4
Congenital Dyserythropoietic Anaemia Type Iv	Anemia, Congenital Dyserythropoietic, 4
Anemia, Dyserythropoietic Congenital, Type Iv	Anemia, Dyserythropoietic, Congenital, Type Iv

Cd45 Deficiency

Hereditary Spherocytosis

Congenital Spherocytic Hemolytic Anemia	Spherocytic Anemia
Congenital Spherocytosis	Spherocytosis, Type 1
Minkowski Chauffard Syndrome	Hs
Minkowski-Chauffard Disease	Minkowski-Chauffard Syndrome
Spherocytosis Hereditary	Spherocytosis, Hereditary
Anemia, Hereditary Spherocytic Hemolytic

Sickle Cell Anemia

Hemoglobin Sc Disease	Anemia, Sickle Cell
Hbsc Disease	Sickle Cell-Hemoglobin C Disease Syndrome
Hb Ss Disease	Sickle Cell Trait
Drepanocytosis	Haemoglobin Sc Disease
Hb Sc Disease	Hb-S/Hb-C Disease
Hb-Ss Disease Without Crisis	Hemoglobin S Disease Without Crisis
Sickle Cell Anaemia	Sickle-Cell/Hb-C Disease Without Crisis
Sickle Cell - Hemoglobin C Disease	Hbs Disease
Hemoglobin S Disease	Sickling Disorder Due To Hemoglobin S
SKCA	Sickle Cell Disease
Sickle Cell-Hemoglobin C Disease	Sickle-Cell Disease Carrier
Sickle-Cell Heterozygous Disorder	Haemoglobin A-S Genotype
Hb-S - [Sickle Cell Haemoglobin] Carrier	Sickle Cell Haemoglobin Trait
As - [Sickle Cell Trait]	Hbas - [Sickle Cell Haemoglobin Trait]
Sickle-Cell Trait Haemoglobin Disease	Haemoglobin Sickle Cell Trait Disorder
Heterozygous Sickle Cell Trait	Hbas - [Heterozygous Haemoglobin S]

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS06515	ICAM4 Human Pre-designed siRNA Set A		/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Felis catus	ICAM4	VGNC	VGNC:80599
Rattus norvegicus	ICAM4	RGD	RGD:1308971
Canis familiaris	ICAM4	VGNC	VGNC:81271
Mus musculus	ICAM4	MGD	MGI:1925619
Bos taurus	ICAM4	VGNC	VGNC:52244
Others	ICAM4	NCBI

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